Unique ID issued by UMIN | UMIN000011225 |
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Receipt number | R000013152 |
Scientific Title | Feasibility study of postoperative adjuvant carboplatin plus nab-paclitaxel for complete resected pathological stage II/IIIA non-small cell lung cancer |
Date of disclosure of the study information | 2013/07/19 |
Last modified on | 2017/07/21 09:26:03 |
Feasibility study of postoperative adjuvant carboplatin plus nab-paclitaxel for complete resected pathological stage II/IIIA non-small cell lung cancer
FASTnab
Feasibility study of postoperative adjuvant carboplatin plus nab-paclitaxel for complete resected pathological stage II/IIIA non-small cell lung cancer
FASTnab
Japan |
completely resected pathological stage II/IIIA non-small cell lung cancer
Pneumology | Endocrine surgery |
Malignancy
NO
To assess the feasibility of postoperative adjuvant carboplatin plus nab-paclitaxel for completely resected pathological stage II/IIIA non-small cell lung cancer
Safety
Completion rate of scheduled adjuvant chemotherapy
Relative dose intensity, Disease-free survival, Overall survival, Incidence and grade of adverse events
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Treatment
Medicine |
carboplatin plus nab-paclitaxel
20 | years-old | <= |
80 | years-old | >= |
Male and Female
1, pathologically confirmed stage II/III non-small cell lung cancer
2, patients who underwent at least lobectomy with selective or systematic lymph nodal dissection
3, patients with complete resection of non-small cell lung cancer
1.History of drug hypersensitivity
2.Serious surgical or non-surgical complications
3.Active secondary cancer.
4.Patient to whom primary doctor judjed inadequate to register.
35
1st name | |
Middle name | |
Last name | Hisashi Saji |
St. Marianna University School of Medicine
Chest Surgery
2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan
1st name | |
Middle name | |
Last name |
St. Marianna University School of Medicine
Chest Surgery
St. Marianna University School of Medicine
St. Marianna University School of Medicine
NO
2013 | Year | 07 | Month | 19 | Day |
Published
https://www.ncbi.nlm.nih.gov/pubmed/28538017
Anticancer Drugs. 2017 Aug;28(7):795-800. doi: 10.1097/CAD.0000000000000512.
Feasibility study of adjuvant chemotherapy with modified weekly nab-paclitaxel
and carboplatin for completely resected non-small-cell lung cancer: FAST-nab.
Saji H(1), Marushima H, Miyazawa T, Sakai H, Kimura H, Kurimoto N, Nakamura H.
Author information:
(1)Department of Chest Surgery, St Marianna University School of Medicine,
Kawasaki, Japan.
The aim of this study was to determine the feasibility of adjuvant administration
of nab-paclitaxel (nab-P) plus carboplatin and for completely resected patients
with stage IB, II, and IIIA non-small-cell lung cancer (NSCLC) (FAST-nab study,
UMIN000011225). Twenty-nine eligible NSCLC patients received surgical resection
for pathological stage IB, II, or IIIA, followed by postoperative adjuvant
chemotherapy with modified 3-week cycles of either nab-P (100?mg/m) on days 1 and
8, followed by carboplatin area (area under the curve=6) on day 1. Twenty-two
(75.9%) of the 29 patients enrolled completed four cycles of this regimen. The
most common grade 3 or 4 adverse event experienced during the nab-P plus
carboplatin was neutropenia (34.5%), followed by anemia (13.8%). No grade 3 or 4
nonhematologic adverse event was observed during this chemotherapy. The median
time to disease recurrence survival was 21 (95% confidence interval: 16-26)
months. The administration of modified nab-P plus carboplatin was considered an
attractive alternative regimen that was safe and well tolerated as a
postoperative adjuvant chemotherapy for completed resected NSCLC.
DOI: 10.1097/CAD.0000000000000512
PMID: 28538017
Completed
2013 | Year | 06 | Month | 04 | Day |
2013 | Year | 07 | Month | 22 | Day |
2013 | Year | 07 | Month | 18 | Day |
2017 | Year | 07 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013152
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