Unique ID issued by UMIN | UMIN000011733 |
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Receipt number | R000013173 |
Scientific Title | New prognostic indexes for overall survival in malignant mesothelioma treated with pemetrexed or best supportive care in the real world |
Date of disclosure of the study information | 2013/09/12 |
Last modified on | 2015/04/11 22:31:32 |
New prognostic indexes for overall survival in malignant mesothelioma treated with pemetrexed or best supportive care in the real world
New prognostic indexes for overall survival in malignant mesothelioma
New prognostic indexes for overall survival in malignant mesothelioma treated with pemetrexed or best supportive care in the real world
New prognostic indexes for overall survival in malignant mesothelioma
Japan |
malignant pleural mesothelioma
Pneumology | Hematology and clinical oncology |
Malignancy
NO
To build prognostic indexes for the malignant pleural mesothelioma patients treated with pemetrexed or best supportive care in the real world
Others
To build prognostic indexes
overall survival
Observational
Not applicable |
Not applicable |
Male and Female
Patients pathologically confirmed with maliganant pleural mesothelioma in Hyogo Prefectural Amagasaki Hospital or Hyogo College of Medicine Hospital between 4/1/2007 to 3/31/2013
Double cancer patients.
Treated by chemotherapy, radiotherapy
before diagnosis.
Treated with trimodality therapy, extra-pleural pneumonectomy, pleurectomy, decortication, or palliative chemotherapy without pemetrexed.
200
1st name | |
Middle name | |
Last name | KATAOKA Yuki |
Kyoto University School of Public Health at Graduate School of Medicine
Department of Healthcare Epidemiology
Yoshida Konoe-cho, Sakyo-ku, Kyoto, JAPAN
075-753-4645
kataoka.yuki.23c@st.kyoto-u.ac.jp
1st name | |
Middle name | |
Last name | KATAOKA Yuki |
Kyoto University School of Public Health at Graduate School of Medicine
Department of Healthcare Epidemiology
Yoshida Konoe-cho, Sakyo-ku, Kyoto, JAPAN
075-753-4645
kataoka.yuki.23c@st.kyoto-u.ac.jp
Kyoto University School of Public Health at Graduate School of Medicine Department of Healthcare Epidemiology
Kyoto University School of Public Health at Graduate School of Medicine Department of Healthcare Epidemiology
Self funding
Hyogo Prefectural Amagasaki Hospital
Hyogo College of Medicine Hospital
NO
2013 | Year | 09 | Month | 12 | Day |
Published
http://www.ncbi.nlm.nih.gov/pubmed/25838292
OBJECTIVE:
Existing prognostic indices for malignant pleural mesothelioma do not incorporate the recent advances in oncology care. The purpose of this study was to provide a prognostic index for overall survival in malignant pleural mesothelioma patients treated with chemotherapy (CTx) with pemetrexed or best supportive care in the recent clinical setting.
METHODS:
A retrospective cohort study was performed in two hospitals in Japan (2007-13). The primary outcome was overall survival. The Cox proportional hazards model was used for multivariable analyses to identify prognostic factors. A final model was chosen based on both clinical and statistical significance.
RESULTS:
A total of 283 patients (CTx: n = 228, best supportive care: n = 55) were enrolled in the study. On multivariate analysis, regimen including platinum plus pemetrexed, a performance status >0, non-epithelial histological type and Stage IV disease predicted poor overall survival in CTx patients. As hazard ratios of individual risk factors were approximately similar, a prognostic index for overall survival was constructed by counting the risk factors. Median overall survival in CTx patients decreased by each one-point increase in this count: 1030 days for zero; 658 days for one; 373 days for two; 327 days for three; 125 days for four. Internal validation using the bootstrapping technique showed robustness of the model (c-index, 0.677; 95% confidence interval, 0.624-0.729). Further, the discrimination was consistent in best supportive care patients (c-index, 0.799; 95% confidence interval, 0.725-0.874).
CONCLUSIONS:
This novel index can provide clinicians and malignant pleural mesothelioma patients with a better framework for discussing prognosis at the time of diagnosis.
Main results already published
2013 | Year | 09 | Month | 12 | Day |
2013 | Year | 09 | Month | 20 | Day |
2014 | Year | 02 | Month | 03 | Day |
2014 | Year | 03 | Month | 10 | Day |
Data extracted from charts are age, gender, ECOG PS, symptoms(chest pain, dyspnea on exertion, body weight loss, appetite loss, fever), smoking history, asbest exposure, comorbidities, histological types, cTNM, stage(IMIG), WBC, neutrophil, lymphocyte, platelet, hemoglobin, alkaly phosphatase, lactate dehydrogenase, C reactive protein, CYFRA21-1, pleural sugar, pleural ADA, pleural CEA, pleural CYFRA21-1
2013 | Year | 09 | Month | 12 | Day |
2015 | Year | 04 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013173
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