Unique ID issued by UMIN | UMIN000011323 |
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Receipt number | R000013269 |
Scientific Title | Relationships between pharmacokinetics, antiemetic effect and adverse effect of prochlorperazine |
Date of disclosure of the study information | 2013/07/31 |
Last modified on | 2014/02/20 21:47:14 |
Relationships between pharmacokinetics, antiemetic effect and adverse effect of prochlorperazine
Relationships between pharmacokinetics, antiemetic effect and adverse effect of prochlorperazine
Relationships between pharmacokinetics, antiemetic effect and adverse effect of prochlorperazine
Relationships between pharmacokinetics, antiemetic effect and adverse effect of prochlorperazine
Japan |
cancer
Medicine in general | Surgery in general |
Malignancy
YES
To evaluate the clinical responses to prochlorperazine based on non-genetic and genetic factors in cancer patients
Safety,Efficacy
Exploratory
Impact of plasma prochlorperazine concentrations and gene polymorphisms on antiemetic effect and serum prolactin level
Observational
Not applicable |
Not applicable |
Male and Female
Cancer patients receiving oral prochlorperazine for the prevention of opioid-induced nausea and vomiting
Patients who (1) discontinued oral prochlorperazine or opioid analgesics during the study; (2) were being co-treated with anticancer drugs; (3) were being co-treated with other dopamine receptor D2 antagonists; (4) were being co-treated with triazole antifungal agents, rifampin, or macrolide antibiotics; (5) were diagnosed as having prolactin-producing adenoma or brain tumors; and (6) were difficult to evaluate with respect to nausea and vomiting.
100
1st name | |
Middle name | |
Last name | Junichi Kawakami |
Hamamatsu University School of Medicine
Department of Hospital Pharmacy
1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan
1st name | |
Middle name | |
Last name | Masaki Tashiro |
Hamamatsu University School of Medicine
Department of Hospital Pharmacy
1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan
Department of Hospital Pharmacy, Hamamatsu University School of Medicine
Department of Hospital Pharmacy, Hamamatsu University School of Medicine
Self funding
NO
2013 | Year | 07 | Month | 31 | Day |
Published
A higher incidence of nausea was observed in patients with DRD2 TaqIA A1.
Female gender altered the incidence of vomiting.
Plasma exposure of prochlorperazine affected serum prolactin concentration.
Patients with OPRM1 118A had a higher serum prolactin concentration.
Completed
2010 | Year | 02 | Month | 01 | Day |
2010 | Year | 02 | Month | 01 | Day |
2013 | Year | 12 | Month | 01 | Day |
2014 | Year | 01 | Month | 01 | Day |
Imapacts of plasma prochlorperazine concentrations and gene polymorphisms on antiemetic effect and serum prolactin level
2013 | Year | 07 | Month | 30 | Day |
2014 | Year | 02 | Month | 20 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013269
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