Unique ID issued by UMIN | UMIN000011421 |
---|---|
Receipt number | R000013343 |
Scientific Title | The influence of perioperative albumin administration to peripheral vascular permeability and extravascular lung water |
Date of disclosure of the study information | 2013/08/08 |
Last modified on | 2015/08/24 11:48:42 |
The influence of perioperative albumin administration to peripheral vascular permeability and extravascular lung water
Perioperative albumin administration
The influence of perioperative albumin administration to peripheral vascular permeability and extravascular lung water
Perioperative albumin administration
Japan |
post operation of oral cavity tumor
Oto-rhino-laryngology | Oral surgery |
Malignancy
NO
Fluid therapy and choice of fluid at the perioperative high permeability state is controversial. Our purpose is that whether the albumin administration affect to the extravascular lung water with using volume view catheter.
Efficacy
Confirmatory
Pragmatic
Not applicable
Primary outcomes is measurement of extravascular lung water and peripheral vascular permeability index at the timing of immediately, 3 hours and 6 hours after administration of albumin. Albumin administration and measurement is repeated 12 hours, 36 hours and 60 hours after operation.
Secondary outcomes is measurement of hemodynamic parameters as following: Heart Rate, Blood Pressure, Cardiac output, Central Venous Pressure, Peripheral Vascular Resistance) and Blood Gas Analysis as following: pH, PaO2 and PaCO2). These measurement is implemented immediately, 3 hours and 6 hours after albumin administration.
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Device,equipment |
Insertion of the arterial line at the femoral artery. Extra vascular Lung water (EVLW) and peripheral vascular permeability index (PVPI) are measured as baseline at the timing of intensive care unit (ICU) admission. 25% albumin is given 12 hours, 36 hours and 60 hours after ICU admission. EVWL and PVPI are measured at immediately, 3 hours and 6 hours after albumin infusion.
18 | years-old | <= |
Not applicable |
Male and Female
Patients who require deep sedation for 72 hours at the intensive care unit after resection of oral cavity tumor and skin flap plasty.
Patients who are under 18 years old and severe pulmonary disease with low respiratory function due to lung resection or chronic obstructive lung disease.
30
1st name | |
Middle name | |
Last name | Shunsuke Takaki |
Yokohama City University Hospital
Intensive Care Unit
3-9 Fukuura Kanazawa Yokohama city Kanagawa prefecture
045-787-2800
shunty5323@gmail.com
1st name | |
Middle name | |
Last name | Shunsuke Takaki |
Yokohama City University Hospital
Intensive Care Unit
3-9 Fukuura Kanazawa Yokohama city Kanagawa prefecture
080-2377-9787
shunty5323@gmail.com
Department of Anesthesiology Yokohama City University Hospital
Department of Anesthesiology Yokohama City University Hospital
Self funding
Japan
NO
横浜市立大学附属病院(神奈川県)
2013 | Year | 08 | Month | 08 | Day |
Partially published
Perioperative albumin administration affect to extra lung water index, but this effect is widely varied depends on inflammatory status after operation.
Completed
2013 | Year | 08 | Month | 08 | Day |
2013 | Year | 08 | Month | 09 | Day |
2015 | Year | 03 | Month | 31 | Day |
2015 | Year | 05 | Month | 20 | Day |
2015 | Year | 05 | Month | 30 | Day |
2015 | Year | 06 | Month | 01 | Day |
2013 | Year | 08 | Month | 08 | Day |
2015 | Year | 08 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013343
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |