Unique ID issued by UMIN | UMIN000011834 |
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Receipt number | R000013834 |
Scientific Title | The effect of astaxanthin treatment on oxidative stress in women |
Date of disclosure of the study information | 2013/10/01 |
Last modified on | 2017/07/17 17:04:18 |
The effect of astaxanthin treatment on oxidative stress in women
Effect of astaxanthin treatment on oxidative stress
The effect of astaxanthin treatment on oxidative stress in women
Effect of astaxanthin treatment on oxidative stress
Japan |
Women in perimenopause and within 5 years after menopause. Inclusion criteria are those with an increased oxidative stress marker: more than 300 Carr Units measured by the Diacron-reactive oxygen metabolites test and low antioxidant state, less than 2000 micro Units, by the biological anti-oxidant potential test.
Obstetrics and Gynecology |
Others
NO
Perimenpausal and early postmenopausal women can have an increase of oxidative stress and decrease of antioxidant potential due to decline in estrogen levels, leading to an increased cardiovascular disease risk. Astaxanthin is known to have an antioxidant capacity and safely used as a supplement. The effect of antioxidant potential of astaxanthin supplementation is not fully reported clinically in the female population. The aim of this study is to observe the effect of astaxanthin supplementation on oxidative stress conditions in perimenpausal and early (within 5 years) postmenopausal women.
Efficacy
Exploratory
Pragmatic
Not applicable
Before, and 4, 8, 12 weeks after the supplement, all participants are interviewed for their medical histories, subjective symptoms, anti-aging common questionnaire, simplified menopausal index, questionnaire for poor circulation, and the status of the supplement. Measurements of body height and weight, blood pressure, and blood oxidative stress measured by the Diacron-reactive oxygen metabolites test and antioxidant state by the biological anti-oxidant potential test.
General blood count, coagulation and fibrinolysis, liver and kidney function, lipids and lipoproteins, inflammatory and oxidative markers, 17-beta E2, FSH, and general urinalysis were measured before and 12 months after the treatment.
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
NO
NO
Institution is not considered as adjustment factor.
NO
Central registration
2
Prevention
Food |
Participants are taken one capsule (an astaxanthin capsule including 12mg of astaxanthin) once a day for 12 weeks.
A placebo capsule is taken one capsule once a day for 12 weeks.
Not applicable |
Not applicable |
Female
Women in perimenopause or within 5 years after menopause. Inclusion criteria are those with an increased oxidative stress marker: more than 300 Carr Units measured by the Diacron-reactive oxygen metabolites test and low antioxidant state, less than 2000 micro Units, by the biological anti-oxidant potential test.
A: women with under 300 Carr Units measured by the Diacron-reactive oxygen metabolites test and a normal antioxidant state, over 2000 micro Units, by the biological anti-oxidant potential test. B: smoker. C: women receiving hormone replacement therapy. D: women taking antioxidant supplements or vitamins. E: women receiving treatment for chronic heart failure, renal failure, hepatitis, or malignancies. F: The doctor approved inappropriate incorporating for this study.
140
1st name | |
Middle name | |
Last name | Jui-Tung Chen |
JT Chen Clinic
Gynecology
B1F, 2-13-5 Akasaka, Minato-Ku Tokyo 1070052
0358560015
jt107smile@gmail.com
1st name | |
Middle name | |
Last name | Jui-Tung Chen |
JT Chen Clinic
Gynecology
B1F, 2-13-5 Akasaka, Minato-Ku Tokyo 1070052
0358560015
http://www.chin-cl.com
jtsmile107@yahoo.co.jp
JT Chen Clinic
JT Chen Clinic
Self funding
NO
陳瑞東クリニック(東京都)
2013 | Year | 10 | Month | 01 | Day |
Published
http://bit.ly/2sZ26Yq
Completed
2012 | Year | 10 | Month | 09 | Day |
2013 | Year | 09 | Month | 24 | Day |
2016 | Year | 09 | Month | 30 | Day |
2016 | Year | 10 | Month | 31 | Day |
2016 | Year | 12 | Month | 31 | Day |
2017 | Year | 01 | Month | 31 | Day |
2013 | Year | 09 | Month | 23 | Day |
2017 | Year | 07 | Month | 17 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013834
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