Unique ID issued by UMIN | UMIN000012185 |
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Receipt number | R000014238 |
Scientific Title | A Danger Signal, Uric Acid/ATP, Attracts and Activates Human Eosinophils |
Date of disclosure of the study information | 2013/10/31 |
Last modified on | 2019/07/16 07:28:52 |
A Danger Signal, Uric Acid/ATP, Attracts and Activates Human Eosinophils
Danger signal induced eosinophils activation
A Danger Signal, Uric Acid/ATP, Attracts and Activates Human Eosinophils
Danger signal induced eosinophils activation
Japan |
bronchial asthma, eosinophilc pneumonia, Hypersensitivity Pneumonitis, sarcoidosis, pneumonia
Pneumology | Clinical immunology |
Others
NO
whether Danger signal can exist in bronchoalveolar lavage fluid for respiratory illness.
Bio-equivalence
Exploratory
Analysis of the bronchoalveolar lavage fluid.
Others,meta-analysis etc
16 | years-old | <= |
80 | years-old | >= |
Male and Female
The patient that respiratory internal medicine is hospitalized in the past and enforces examination with broncho fiber scope, and there is a preservation specimen of the bronchoalveolar lavage fluid
The patient who cannot confirm the details of the medical history
100
1st name | Takehito |
Middle name | |
Last name | Kobayashi |
Saitama Medical University Hospital
Department of General Internal Medicine
350-0495
38 Morohongo Moroyamamachi Irumagun Saitama, Japan
049-276-1667
kobatake@saitama-med.ac.jp
1st name | Takehito |
Middle name | |
Last name | Kobayashi |
Saitama Medical University Hospital
Department of General Internal
350-0495
38 Morohongo Moroyamamachi Irumagun Saitama, Japan
049-276-1667
kobatake@saitama-med.ac.jp
Saitama Medical University Hospital
The Ministry of Education, Culture, Sports, Science and Technology(MEXT)
Grant-in-Aid for Scientific Research (KAKENHI)
Grant-in-Aid for Young Scientists(B)
Japanese Governmental office
Saitama Medical University Hospital Hospital IRB
38 Morohongo Moroyamamachi Irumagun Saitama, Japan
049-276-1354
hirb@saitama-med.ac.jp
NO
2013 | Year | 10 | Month | 31 | Day |
https://www.ncbi.nlm.nih.gov/pubmed/26344078 , https://www.ncbi.nlm.nih.gov/pubmed/28705588
Published
https://www.ncbi.nlm.nih.gov/pubmed/26344078 , https://www.ncbi.nlm.nih.gov/pubmed/28705588
30
The substance released by tissue invasion and affecting the immune response is called Danger signal.
The Danger signal UA / ATP induces eosinophil activation.
In vitro, UA / ATP induced adhesion reaction, migration reaction, activation of eosinophils.
In Vivo, consistent results were obtained by analysis of BALF of AEP.
2019 | Year | 07 | Month | 16 | Day |
2016 | Year | 03 | Month | 31 | Day |
Eosinophilic pneumonia
Healthy person
hospitalized patient
nothing
Clinical symptoms
Completed
2012 | Year | 04 | Month | 01 | Day |
2015 | Year | 03 | Month | 31 | Day |
2013 | Year | 04 | Month | 01 | Day |
2016 | Year | 03 | Month | 31 | Day |
2017 | Year | 03 | Month | 31 | Day |
2017 | Year | 03 | Month | 31 | Day |
2017 | Year | 03 | Month | 31 | Day |
Retrospective study
2013 | Year | 10 | Month | 31 | Day |
2019 | Year | 07 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014238
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