Unique ID issued by UMIN | UMIN000012234 |
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Receipt number | R000014307 |
Scientific Title | The PRebiotics Effect on Endotoxinemia in type 2 Diabetes |
Date of disclosure of the study information | 2013/11/11 |
Last modified on | 2022/05/27 14:57:24 |
The PRebiotics Effect on Endotoxinemia in type 2 Diabetes
PREED
The PRebiotics Effect on Endotoxinemia in type 2 Diabetes
PREED
Japan |
type 2 Diabetes
Endocrinology and Metabolism |
Others
NO
We investigate the effect of GOS on endotoxinemia in type 2 diabetes.
Safety,Efficacy
serum LBP,LPS
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
2
Treatment
Food |
GOS
placebo
20 | years-old | <= |
65 | years-old | >= |
Male and Female
type 2 diabetes treated over 3 months
patients prescribed alpha-GI and antibiotics
60
1st name | Kumiko |
Middle name | |
Last name | Hamano |
Kantoh Rosai Hospital
diabetes and endoclinology
211-8510
Kanagawa-prefecture Kawasaki-city Nakahara-ku Kizukisumiyoshicho 1-1
044-411-3131
teamdm@kantoh.rofuku.go.jp
1st name | Hiroko |
Middle name | |
Last name | Kato |
Kantoh Rosai Hospital
diabetes and endoclinology
211-8510
Kanagawa-prefecture Kawasaki-city Nakahara-ku Kizukisumiyoshicho 1-1
044-411-3131
teamdm@kantoh.rofuku.go.jp
Kantoh Rosai Hospital
Yakult
Profit organization
Kantoh Rosai Hospital IRB
1-1 Kizukisumiyoshi,Nakahara, Kawasaki, Kangata, Japan
044-411-3131
teamdm@kantoh.rofuku.go.jp
NO
関東労災病院(神奈川県)
2013 | Year | 11 | Month | 11 | Day |
https://www.wageningenacademic.com/doi/abs/10.3920/BM2016.0230
Partially published
https://www.wageningenacademic.com/doi/abs/10.3920/BM2016.0230
116
Levels of FPG, HbA1c, ALT, and TG in DMAG were significantly higher than those in CG.
2022 | Year | 05 | Month | 27 | Day |
Sex (male/female; n)14/16 29/11
Following recruitment, we asked CG and DMG subjects to submit fresh faecal samples to investigate gut microbiota and their metabolic products. We then took blood samples from all participants to measure various biochemical parameters, including LBP, LPS, IL-6, IL-10, and TNF-a. DMG were randomly assigned to receive either 10 g/d GOS syrup (Oligomate55N; Yakult Pharmaceutical Industry, Tokyo, Japan) or 10 g/d maltodextrin syrup as a placebo for 4 weeks (Supplementary Table S1). GOS and placebo had a similar package and taste, and both participants and main investigators remained blind until the end of this study. After 4 weeks of syrup intake, both the GOS group and placebo group provided faecal and blood samples, and the same parameters were measured again. Finally, all patients answered brief questionnaires about the frequency of consumption of yogurt and probiotic or prebiotic supplements.
none
gut microbiota
Levels of FPG, HbA1c, ALT, and TG, LBP, LPS, IL-6, IL-10, and TNF-a
Completed
2013 | Year | 09 | Month | 11 | Day |
2013 | Year | 12 | Month | 01 | Day |
2013 | Year | 12 | Month | 01 | Day |
2014 | Year | 02 | Month | 28 | Day |
2013 | Year | 11 | Month | 07 | Day |
2022 | Year | 05 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014307
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