Unique ID issued by UMIN | UMIN000012378 |
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Receipt number | R000014471 |
Scientific Title | Effect of ALDH2 polymorphism, gastric acid secretion level, and L-cystein administration on gastric acetaldehyde concentration |
Date of disclosure of the study information | 2013/11/25 |
Last modified on | 2015/04/30 18:25:17 |
Effect of ALDH2 polymorphism, gastric acid secretion level, and L-cystein administration on gastric acetaldehyde concentration
Effect of ALDH2 polymorphism, gastric acid secretion level, and L-cystein administration on gastric acetaldehyde concentration
Effect of ALDH2 polymorphism, gastric acid secretion level, and L-cystein administration on gastric acetaldehyde concentration
Effect of ALDH2 polymorphism, gastric acid secretion level, and L-cystein administration on gastric acetaldehyde concentration
Japan |
healthy volunterrs
Gastroenterology |
Others
YES
The aim of this study is to investigate how suppression of gastric acid secretion and/or ALDH2 polymorphism affects acetaldehyde formation in the stomach in healthy volunteers. Then, we also investigate whether L-cystein could effectively eliminate acetaldehyde formed in the hypochlorhydric stomach not only in ALDH2-active subjects but also in ALDH2-deficient subjects.
Efficacy
Change of gastric acetaldehyde concentration among baseline, on PPI, and on PPI plus L-cystein
Interventional
Factorial
Non-randomized
Open -but assessor(s) are blinded
No treatment
2
Treatment
Medicine | Food |
proton pump inhibito
proton pump inhibito, L-cystein
20 | years-old | <= |
Not applicable |
Male
H. pylori-negative healthy male volunteers
ALDH2 dufficient subjects
20
1st name | |
Middle name | |
Last name | Iijima Katsunori |
Tohoku University Hospital
Div. of Gastroenterology
1-1 Seiryo-machi, Aobaku, Sendai 980-8574
022-717-7171
kiijima@med.tohoku.ac.jp
1st name | |
Middle name | |
Last name | Iijima Katsunori |
Tohoku University Hospital
Div. of Gastroenterology
1-1 Seiryo-machi, Aobaku, Sendai 980-8574
022-717-7171
kiijima@med.tohoku.ac.jp
Div. of Gastroenterology, Tohoku University Hospital
none
Other
NO
2013 | Year | 11 | Month | 25 | Day |
Unpublished
Open public recruiting
2012 | Year | 10 | Month | 23 | Day |
2013 | Year | 01 | Month | 01 | Day |
2013 | Year | 11 | Month | 21 | Day |
2015 | Year | 04 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014471
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