Unique ID issued by UMIN | UMIN000012405 |
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Receipt number | R000014514 |
Scientific Title | Postoperative atrial fibrillation and insulin resistance in cardiovascular surgery |
Date of disclosure of the study information | 2013/11/27 |
Last modified on | 2016/07/05 21:31:01 |
Postoperative atrial fibrillation and insulin resistance in cardiovascular surgery
Postoperative atrial fibrillation and insulin resistance
Postoperative atrial fibrillation and insulin resistance in cardiovascular surgery
Postoperative atrial fibrillation and insulin resistance
Japan |
valvular heart disease, angina, myocardial infarction, thoracic aortic aneurysm
Cardiovascular surgery |
Others
NO
To examine whether postoperative atrial fibrillation and electromechanical delay correlate with systemic insulin resistance and myocardial calcium handling proteins.
Others
Study of molecular biology in a condition of disease
Exploratory
Correlation between postoperative atrial fibrillation and myocardial calcium handling proteins.
Correlation between myocardial electromechanical delay and systemic insulin resistance; Postoperative major events.
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Maneuver |
Resection of right atrial tissue (5X5 mm) during the procedure for establishment of cardiopulmonary bypass.
20 | years-old | <= |
Not applicable |
Male and Female
Patients undergoing cardiovascular surgery by full sternotomy: on-pump coronary artery bypass grafting, heart valve surgery, and surgery for thoracic aortic aneurysm.
no informed consent; urgent or emergent surgery; under another interventional study
50
1st name | |
Middle name | |
Last name | Yoshiro Matsui |
Hokkaido university hospital
Cardiovascular and Thoracic Surgery
Kita14, Nishi5, Kitaku, Sapporo, Japan
011-706-6042
ymatsui@med.hokudai.ac.jp
1st name | |
Middle name | |
Last name | Yasushige Shingu |
Hokkaido university hospital
Cardiovascular and Thoracic Surgery
Kita14, Nishi5, Kitaku, Sapporo, Japan
011-706-6042
shingu@huhp.hokudai.ac.jp
Cardiovascular and Thoracic Surgery, Hokkaido university hospital
Japan Society for the Promotion of Science
Other
Japan
NO
北海道大学病院
2013 | Year | 11 | Month | 27 | Day |
Unpublished
Subjects were 38 patients who underwent cardio-thoracic surgery. Twenty-four-hours monitoring by electrocardiogram was conducted for the detection of postoperative atrial fibrillation for 7 days after surgery. Myocardial specimen excised from the right atrium during operation was quickly frozen and stored for the gene expression analysis of glucose and fatty acid metabolism. Eighteen patients (47%) presented with postoperative atrial fibrillation (POAF group). The patients in POAF group tended to have higher fasted glucose level preoperatively. The gene expression of fatty acid binding protein 3 (FABP3) - fatty acid transporter in myocytes - was significantly reduced in the POAF group than in the non-POAF group. Moreover, in the analysis of 12 patients with insulin resistance, the gene expression of cluster of differentiation 36 / fatty acid translocase (CD36) - fatty acid transporter into myocytes - tended to be higher in the POAF group than in the non-POAF group (P=0.08). We demonstrated that there is a correlation between POAF and abnormal gene expression of fatty acid metabolism in the myocardium.
Completed
2013 | Year | 11 | Month | 19 | Day |
2013 | Year | 11 | Month | 27 | Day |
2013 | Year | 11 | Month | 26 | Day |
2016 | Year | 07 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014514
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