Unique ID issued by UMIN | UMIN000012682 |
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Receipt number | R000014819 |
Scientific Title | Impact of Gene Polymorphism on Platelet Reactivity and Clinical Outcomes During Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Coronary Heart Disease |
Date of disclosure of the study information | 2013/12/25 |
Last modified on | 2018/12/30 07:36:39 |
Impact of Gene Polymorphism on Platelet Reactivity and Clinical Outcomes During Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Coronary Heart Disease
Gene Polymorphism During Dual Antiplatelet Therapy
Impact of Gene Polymorphism on Platelet Reactivity and Clinical Outcomes During Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Coronary Heart Disease
Gene Polymorphism During Dual Antiplatelet Therapy
Japan |
Coronary artery disease
Cardiology |
Others
YES
To evaluate the impact of gene polymorphism on cardiovascular event during dual antiplatelet therapy with aspirin and clopidogrel
Others
assessment of pathophysiology
Residual platelet reactivity and cardiovascular event
Observational
Not applicable |
Not applicable |
Male and Female
We firstly registered patients who underwent PCI in Kumamoto University Hospital, and enrolled patients with dual antiplatelet therapy including aspirin and clopidogrel
1.known allergy to aspirin or clopidogrel
2. thrombocytopenia
3. severe liver dysfunction
4. malignant disease with severe prognosis
5. patients taking other antithrombotic agents
500
1st name | |
Middle name | |
Last name | Hisao Ogawa |
Graduate School of Medical Sciences, Kumamoto University
Department of Cardiovascular Medicine
1-1-1, Honjo, Chuo-ku, Kumamoto City
096-373-5175
cvmhisho@kumamoto-u.ac.jp
1st name | |
Middle name | |
Last name | Seiji Hokimoto |
Graduate School of Medical Sciences, Kumamoto University
Department of Cardiovascular Medicine
1-1-1, Honjo, Chuo-ku, Kumamoto City
096-373-5175
shokimot@kumamoto-u.ac.jp
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
The Ministry of Education, Science, and Culture in Japan
Japanese Governmental office
NO
2013 | Year | 12 | Month | 25 | Day |
Partially published
Cardiovascular event risk following coronary stent implantation was increased in patients with CYP2C19 loss-of-function allele. However, the effect of CYP2C19 polymorphism depends on the presence of ACS or diabetes mellitus.
Enrolling by invitation
2013 | Year | 12 | Month | 25 | Day |
2013 | Year | 12 | Month | 25 | Day |
We examined patients monthly after discharge and performed a follow-up angiography during 6 to 12 months after the procedure. Then, we followed patients every 6 months in the outpatient department after the re-study and surveyed by phone calls to subjects and their families in the absence of hospital visiting.
2013 | Year | 12 | Month | 25 | Day |
2018 | Year | 12 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014819
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