Unique ID issued by UMIN | UMIN000012832 |
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Receipt number | R000014989 |
Scientific Title | Panitumumab plus mFOLFOX6 therapy for colorectal cancer patients of RAS wild with potential resectable metastases in relation to early tumor shrinkage |
Date of disclosure of the study information | 2014/01/15 |
Last modified on | 2016/11/16 09:10:11 |
Panitumumab plus mFOLFOX6 therapy for colorectal cancer patients of RAS wild with potential resectable metastases in relation to early tumor shrinkage
Panitumumab plus mFOLFOX6 therapy for RAS wild
Panitumumab plus mFOLFOX6 therapy for colorectal cancer patients of RAS wild with potential resectable metastases in relation to early tumor shrinkage
Panitumumab plus mFOLFOX6 therapy for RAS wild
Japan |
colorectal cancer with potential resectable metastases
Gastrointestinal surgery |
Malignancy
NO
To evaluate early tumor shrinkage of potentially resectable metastases of colorectal cancer with Panitumumab plus modified FOLFOX 6
Safety,Efficacy
Early tumor shrinkage(at the point of 8 weeks)
Observational
20 | years-old | <= |
80 | years-old | >= |
Male and Female
(1)histologically confirmed advanced mCRC
ecept cancer of appendix and anal canal
(2)Operable
(3)RAS wild tye
(4)Writen informed consent
(5)Age: 20-80 years
(6)Performance status (PS) 0-1
(7)Alife expectancy greater than 12 weeks
(8)Metastases classified in Group 1 of
ESMO Consensus Guidline
(9)Adequate organ function
(1)Pleural effision or ascites or pericardial effusion to be discharged
(2)Multiple malignacies to be treated
(3)bleeding tendency(PT-INR ;1.5)
(4)Ileus,uncontrollable peptic ulcer disease
(5)Serious complications (DM, infection, diarrhea)
(6)Serious heart disease
(7)Previous history of severe drug-induced allergy
(8)Severe neuropathy
(9)With interstitial lung disease or pulmonary fibrosis
(10)Pregnant
(11)Disqualified by attending doctor
30
1st name | |
Middle name | |
Last name | Yasuiro Kodera |
Nagoya University Graduate School of Medicine
Gastroenterological Surgery
65 Tsurumai-cho Showa-ku Nagoya,466-8550,Japan
052-744-2253
ykodera@med.nagoya-u.ac.jp
1st name | |
Middle name | |
Last name | Goro Nakayama |
Nagoya University Graduate School of Medicine
Gastroenterological Surgery
65 Tsurumai-cho Showa-ku Nagoya,466-8550,Japan
052-744-2253
goro@med.nagoya-u.ac.jp
Chubu Clinical Oncology Group(CCOG)
none
Self funding
NO
2014 | Year | 01 | Month | 15 | Day |
Unpublished
Enrolling by invitation
2014 | Year | 03 | Month | 17 | Day |
2014 | Year | 04 | Month | 01 | Day |
To evaluate early tumor shrinkage with panitumumab plus modified FOLFOX6 in the first-line setting
2014 | Year | 01 | Month | 12 | Day |
2016 | Year | 11 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014989
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