Unique ID issued by UMIN | UMIN000012912 |
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Receipt number | R000015095 |
Scientific Title | Serum ferritin, HO-1, and CD163 for the diagnosis of adult-onset Still's disease: a multicenter study |
Date of disclosure of the study information | 2014/01/21 |
Last modified on | 2020/01/27 14:32:20 |
Serum ferritin, HO-1, and CD163 for the diagnosis of adult-onset Still's disease: a multicenter study
Serum ferritin, HO-1, and CD163 in adult-onset Still's disease
Serum ferritin, HO-1, and CD163 for the diagnosis of adult-onset Still's disease: a multicenter study
Serum ferritin, HO-1, and CD163 in adult-onset Still's disease
Japan |
Definite and suspected adult-onset Still's disease, systemic-onset juvenile idiopathic arthritis, rheumatic diseases, infectious diseases, malignancies
Medicine in general | Hematology and clinical oncology | Clinical immunology |
Adult | Child |
Others
NO
Yamaguchi's criteria is sensitive and specific for the diagnosis of adult-Still's disease (AOSD) and has been used worldwide over the past few decades. However, elevation of serum ferritin, which is a specific in the disease, is not included in the criteria. Moreover, differential diagnosis with infectious diseases, malignancies, and rheumatic diseases are difficult.
Others
To improve the sensitivity and specificity for the diagnosis of AOSD, we are planning to measure serum ferritin, HO-1, and CD163, and evaluate their use in the diagnosis of AOSD along with the components in Yamaguchi's criteria. We also planning to monitor these markers during the course of disease.
Others
Others
Not applicable
Diagnosis of adult-onset Still's disease
Major and minor components in Yamaguchi's criteria, laboratory data, serum ferritin, HO-1, and serum CD163
Parallel
Non-randomized
Open -no one is blinded
Uncontrolled
2
Diagnosis
Other |
Blood examination
Blood examination
Not applicable |
Not applicable |
Male and Female
Adult-onset Still's disease cases fulfilling Yamaguchi's criteria, and suspected cases, established cases for diagnosis of rheumatic diseases, infectious diseases, and malignancies, healthy controls.
None
400
1st name | |
Middle name | |
Last name | Yoshiaki Ishigatsubo |
Yokohama City University Graduate School of Medicine
Department of Internal Medicine and Clinical Immunology
3-9 Fukuura, Kanazawa-ku, Yokohama
045-787-2630
ishigats@med.yokohama-cu.ac.jp
1st name | |
Middle name | |
Last name | Yohei Kirino |
Yokohama City University Graduate School of Medicine
Department of Internal Medicine and Clinical Immunology
3-9 Fukuura, Kanazawa-ku, Yokohama
045-787-2630
kirino@yokohama-cu.ac.jp
Yokohama City University Graduate School of Medicine, Department of Internal Medicine and Clinical Immunology
Donations from profit organizations
Profit organization
Uehara Memorial Fundation
Yokohama Medical Foundation for Advancement of Medical Science
NO
佐賀大学医学部附属病院(佐賀県)
早良病院(福岡県)
飯塚病院(福岡県)
自治医科大学附属病院(栃木県)
横浜市立大学市民総合医療センター(神奈川県)
鹿児島大学病院(鹿児島県)
九州大学別府病院 大分県)
札幌医科大学医学部附属病院(北海道)
東京女子医科大学病院(東京都)
聖マリアンナ医科大学病院(神奈川県)
九州大学病院(福岡県)
2014 | Year | 01 | Month | 21 | Day |
Unpublished
Completed
2014 | Year | 01 | Month | 10 | Day |
2014 | Year | 01 | Month | 10 | Day |
2014 | Year | 01 | Month | 10 | Day |
2017 | Year | 01 | Month | 09 | Day |
2017 | Year | 01 | Month | 09 | Day |
2014 | Year | 01 | Month | 21 | Day |
2020 | Year | 01 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015095
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