Unique ID issued by UMIN | UMIN000012956 |
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Receipt number | R000015148 |
Scientific Title | The evaluation of acute vascular damage induced by platinum-based chemotherapy |
Date of disclosure of the study information | 2014/01/25 |
Last modified on | 2014/01/25 08:11:52 |
The evaluation of acute vascular damage induced by platinum-based chemotherapy
Platinum-based chemotherapy and vascular damage
The evaluation of acute vascular damage induced by platinum-based chemotherapy
Platinum-based chemotherapy and vascular damage
Japan |
gynecological cancer
Obstetrics and Gynecology |
Malignancy
NO
The aim of this study was to evaluate the influence of PtChem on the vascular endothelial function and determine whether bezafibrate prevents endothelial dysfunction in gynecological cancer patients.
Efficacy
Confirmatory
Explanatory
Not applicable
The change of the flow-mediated dilation (FMD), serum pentraxin-3
Parallel
Non-randomized
Open -no one is blinded
No treatment
3
Prevention
Medicine |
The patients exhibiting hypertriglyceridemia during chemotherapy were administered Bezafibrate
No medication with bezafibrate for the patients exhibiting hypertriglyceridemia during chemotherapy.
the patients exhibiting normal triglyceride level.
20 | years-old | <= |
Not applicable |
Female
ovarian cancer or endometrial cancer patients who are going to receive adjuvant chemotherapy after surgical treatment.
Participants who had received prior treatment for cancer and those with a history of cardiovascular disease (myocardial infarction, stroke, peripheral arterial thrombosis) or decompensated diabetes were excluded from this study. The exclusion criteria also included a history of clinically significant gastrointestinal, liver or gallbladder disease, treatment with lipid- or glucose-lowering agents and the use of hormone replacement therapy within the previous one year.
100
1st name | |
Middle name | |
Last name | Masahid Ohmivhi |
Osaka Medical College
Obstetrics and Gynecology
2-7 Daigaku-machi, Takatsuki city, Osaka
+81-72-683-1221
gyn074@poh.osaka-med.ac.jp
1st name | |
Middle name | |
Last name | Akiko Tanabe |
Osaka Medical College
Obstetrics and Gynecology
2-7 Daigaku-machi, Takatsuki city, Osaka
+81-72-683-1221
gyn074@poh.osaka-med.ac.jp
Dept of Obstetrics and Gynecology, Osaka Medical College
Grant-in-Aid for Scientific Research 24592535 (to A.T.) from the Ministry of Education, Science and Culture of Japan
NO
2014 | Year | 01 | Month | 25 | Day |
Partially published
The administration of TC induced hypertriglyceridemia in 2/3 of the participants, with that of bezafibrate reduced the serum TG levels. Meanwhile, the decrease in %FMD induced by TC improved following treatment with bezafibrate. The serum pentraxin-3 level increased rapidly after TC and decreased following bezafibrate treatment.
Completed
2010 | Year | 01 | Month | 04 | Day |
2010 | Year | 01 | Month | 07 | Day |
2012 | Year | 11 | Month | 29 | Day |
2013 | Year | 12 | Month | 31 | Day |
2013 | Year | 12 | Month | 31 | Day |
2014 | Year | 04 | Month | 30 | Day |
2014 | Year | 01 | Month | 25 | Day |
2014 | Year | 01 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015148
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