Unique ID issued by UMIN | UMIN000013081 |
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Receipt number | R000015261 |
Scientific Title | Plasma connective tissue growth factor (CTGF) as a surrogate biomarker in asthma. |
Date of disclosure of the study information | 2014/02/05 |
Last modified on | 2014/02/05 15:53:32 |
Plasma connective tissue growth factor (CTGF) as a surrogate biomarker in asthma.
Plasma CTGF in asthma.
Plasma connective tissue growth factor (CTGF) as a surrogate biomarker in asthma.
Plasma CTGF in asthma.
Japan |
asthma
Pneumology | Clinical immunology |
Others
NO
The aim of the present study is to investigate the utility of plasma CTGF level as a surrogate biomarker in asthma.
Efficacy
Others
Others
Not applicable
Correlations between plasma CTGF levels and airway obstruction in patients with asthma.
Correlations between plasma CTGF levels and other clinical parameters in patients with asthma.
Observational
20 | years-old | <= |
Not applicable |
Male and Female
1. Classified as "controlled" under adequate treatment according to the GINA criteria of asthma control
2. Free from asthma symptoms, limitations of activities, exacerbation, and had no more than two rescue treatments a week even when required.
3. Received ICS, the mainstay of anti-inflammatory therapy in asthma, or ICS plus other antiasthmatic drugs for 1 year or more, with no change in dose within the previous 8 weeks.
1) treatment with oral or intravenous corticosteroids in the previous 4 weeks,
2) having a smoking history more than 10 pack-years,
3) having other pulmonary diseases including chronic obstructive pulmonary disease.
60
1st name | |
Middle name | |
Last name | Takafumi Suda |
Hamamatsu University School of Medicine
Second division, Department of Internal Medicine
1-20-1 Handayama, Hamamatsu 431-3192, Japan
053-435-2261
suda@hama-med.ac.jp
1st name | |
Middle name | |
Last name | Tomoyuki Fujisawa |
Hamamatsu University School of Medicine
Second division, Department of Internal Medicine
1-20-1 Handayama, Hamamatsu 431-3192, Japan
053-435-2261
fujisawa@hama-med.ac.jp
Hamamatsu University School of Medicine
none
Self funding
NO
2014 | Year | 02 | Month | 05 | Day |
Unpublished
Plasma CTGF levels were higher in patients with asthma than healthy volunteers. Plasma CTGF levels showed significantly negative correlations with forced expiratory volume in 1 second (FEV1), FEV1 percentage of the predicted value (%pred), forced expiratory flow at 50% of the forced vital capacity (FEF50), FEF50 %pred, FEF75, and FEF75 %pred, parameters reflecting the degree of airway obstruction, in patients with asthma.
Completed
2009 | Year | 02 | Month | 01 | Day |
2009 | Year | 03 | Month | 01 | Day |
Plasma CTGF levels negatively correlated with the Asthma Control Test scores, patient-based index of clinical control of asthma.
2014 | Year | 02 | Month | 05 | Day |
2014 | Year | 02 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015261
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