Unique ID issued by UMIN | UMIN000013154 |
---|---|
Receipt number | R000015337 |
Scientific Title | A clinical study of relevance to KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer |
Date of disclosure of the study information | 2014/04/01 |
Last modified on | 2016/02/15 09:42:54 |
A clinical study of relevance to KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
A relevance to KRAS mutations and acquired resistance to anti-EGFR therapy
A clinical study of relevance to KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
A relevance to KRAS mutations and acquired resistance to anti-EGFR therapy
Japan |
Colorectal cancer
Hematology and clinical oncology | Gastrointestinal surgery |
Malignancy
NO
It has been reported that kras mutatation has been emerged in kras wild type colorectal cancer after using anti-EGFR agent. By use of anti-EGFR agent, kras mutant selectively amplified, and then become resistance to anti-EGFR agent, from a part of colorectal cancer cells having kras mutation. In this study, we analyze kras mutation and other relative gene mutations in serum circulating DNA.
Bio-equivalence
Confirmatory
Pragmatic
Not applicable
Detection of kras mutation in serum circulation DNA
Detection of other mutations related colorectal cancer in serum circulation DNA
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients with Kras wild type advance or recurrent colorectal cancer and will be treated with an anti-EGFR antibody
He or she had used anti-EGFR antibody previously, or prohibit on using anti-EGFR antibody
20
1st name | |
Middle name | |
Last name | Yasuo Saijo |
Niigata University Graduate School of Medical and Dental Sciences
Department of Medical Oncology
1-757 Asahimachidori Chuohku, Niigata, 951-8510 Japan
025-368-9003
yasosj@med.niigata-u.ac.jp
1st name | |
Middle name | |
Last name | Yasuo Saijo |
Niigata University Graduate School of Medical and Dental Sciences
Department of Medical Oncology
1-757 Asahimachidori Chuohku, Niigata, 951-8510 Japan
025-368-9003
yasosj@med.niigata-u.ac.jp
Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences
Niigata University Medical and Dental Hospital
Other
NO
2014 | Year | 04 | Month | 01 | Day |
Unpublished
Completed
2012 | Year | 09 | Month | 26 | Day |
2012 | Year | 10 | Month | 01 | Day |
Detection of kras mutation in serum circulation DNA
2014 | Year | 02 | Month | 13 | Day |
2016 | Year | 02 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015337
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |