Unique ID issued by UMIN | UMIN000013478 |
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Receipt number | R000015735 |
Scientific Title | Extended infusion of dripenem for sepsis in hepatopoietic stem cell transplantatation; pharmacokinetic study |
Date of disclosure of the study information | 2014/04/01 |
Last modified on | 2015/03/23 15:51:05 |
Extended infusion of dripenem for sepsis in hepatopoietic stem cell transplantatation; pharmacokinetic study
Extended infusion of dripenem; pharmacokinetic study
Extended infusion of dripenem for sepsis in hepatopoietic stem cell transplantatation; pharmacokinetic study
Extended infusion of dripenem; pharmacokinetic study
Japan |
Sepsis in hematopoietic stem cell transplantatation
Medicine in general | Hematology and clinical oncology |
Malignancy
NO
Pharmacokinetic evaluation of dripenem(3g/day) in extnded infusion
Pharmacokinetics
Confirmatory
High time above MIC in extnded infusion (4 hour) of dripenem (3g/day)
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Treatment
Medicine |
Extended infusion (4 hour) of dripenem
Analysis of blood concentration (dripenem)
20 | years-old | <= |
Not applicable |
Male and Female
1. Patient received hematopoietic stem cell transplantatation for hematological malignancy
2. 20-year old or older
3. Patient using central venous catheter
1. Allergic history of carbapenem or beta-lactam antibiotics
2. Hepatic disorder with grade II or above
3. Renal disorder; less than 70ml/min./1.73m2 (eGFR)
4. Prophylactic antibiotics for bacterial infection except for quinolones
5. Treatment with antifungal drugs
6. Ineligible decision by physician
7. Repeated inclusion of patient
8. Patient without central venous catheter
5
1st name | |
Middle name | |
Last name | Akihito Shinohara |
Graduate school of medicine, The university of Tokyo
Department of hematology and oncology
7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
+81-3-3815-5411
sinohaa-tky@umin.ac.jp
1st name | |
Middle name | |
Last name | Akihito Shinohara |
Graduate school of medicine, The university of Tokyo
Department of hematology and oncology
7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
+81-3-3815-5411
sinohaa-tky@umin.ac.jp
Department of hematology and oncology, graduate school of medicine, The university of Tokyo
Department of hematology and oncology, graduate school of medicine, The university of Tokyo
Other
NO
2014 | Year | 04 | Month | 01 | Day |
Unpublished
Terminated
2013 | Year | 09 | Month | 07 | Day |
2013 | Year | 09 | Month | 07 | Day |
2014 | Year | 03 | Month | 21 | Day |
2015 | Year | 03 | Month | 23 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015735
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