Unique ID issued by UMIN | UMIN000013555 |
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Receipt number | R000015838 |
Scientific Title | Clinical survey of patients with cerebrovascular diseases (MBs study) |
Date of disclosure of the study information | 2014/04/01 |
Last modified on | 2015/09/01 22:29:36 |
Clinical survey of patients with cerebrovascular diseases (MBs study)
Clinical survey of patients with cerebrovascular diseases (MBs study)
Clinical survey of patients with cerebrovascular diseases (MBs study)
Clinical survey of patients with cerebrovascular diseases (MBs study)
Japan |
Cerebrovascular diseases
Medicine in general | Neurology | Geriatrics |
Others
NO
To survey the clinical characteristics of patients with cerebrovascular diseases
Others
To clarify the clinical characteristics of patients with cerebrovascular diseases and whether various risk factors including renal impairment could be associated with their outcomes, such as discharge destinations and long-term mortalities.
Confirmatory
Pragmatic
Not applicable
functional outcome, discharge destinations, and long-term mortality
Observational
Not applicable |
Not applicable |
Male and Female
Between April 2007 and March 2013, patients with acute ischemic stroke who were admitted to our hospital within 24 hours of stroke onset.
Patients with recurrence of stroke were excluded.
2000
1st name | |
Middle name | |
Last name | Naoki Saji |
Kawasaki Medical School
Department of Stroke Medicine
577 Matsushima, Kurashiki, Okayama
086-462-1111
sajink@nifty.com
1st name | |
Middle name | |
Last name | Naoki Saji |
Kawasaki Medical School
Department of Stroke Medicine
577 Matsushima, Kurashiki, Okayama
086-462-1111
sajink@nifty.com
Kawasaki Medical School
Kawasaki Medical School
Self funding
NO
川崎医科大学(岡山県)
2014 | Year | 04 | Month | 01 | Day |
http://www.strokejournal.org/article/S1052-3057(15)00396-1/fulltext
Published
http://www.strokejournal.org/article/S1052-3057(15)00396-1/fulltext
International Stroke Conference 2014
Completed
2013 | Year | 07 | Month | 01 | Day |
2013 | Year | 07 | Month | 01 | Day |
2014 | Year | 03 | Month | 28 | Day |
2014 | Year | 03 | Month | 28 | Day |
2014 | Year | 03 | Month | 29 | Day |
2014 | Year | 04 | Month | 08 | Day |
Background: Cerebral small-vessel disease (SVD) is associated with renal dysfunction such as chronic kidney disease. Although cerebral microbleeds (CMBs) are common in patients with acute lacunar infarcts (ALI), the association between renal dysfunction and CMBs in such patients remains unclear.
Methods: Between April 2007 and March 2013, we evaluated consecutive first-ever ALI patients, who were admitted to our hospital within 24 hours of stroke onset. CMBs were defined as focal areas of signal loss in brain parenchyma less than 5 mm on T2* weighted gradient-echo imaging. Renal dysfunction was defined as an estimated glomerular filtration rate less than 60 mL/minute/1.73 m2 on admission. Correlations between renal dysfunction and the presence (model 1) and location of CMBs (model 2; any deep or infratentorial CMBs) were determined by multivariable logistic regression analyses.
Results: Among 152 patients (33.6% men; mean age, 67.6 years), 53 had CMBs. Patients with CMBs were older (69.9 versus 66.3 years, P = .03) and had a higher frequency of white matter hyperintensity (WMH; 62.3% versus 25.3%, P < .001), silent lacunar infarcts (SLI; 75.5% versus 43.3%, P < .001), and renal dysfunction (41.5% versus 22.2%, P = .015) than those without CMBs. On multivariable analyses, renal dysfunction (odds ratio, 95% confidence interval; model 1: 2.38, 1.02-5.66; model 2: 2.78, 1.16-6.81), WMH (3.87, 1.76-8.80; 3.72, 1.64-8.71), SLI (3.85, 1.71-9.14; 4.20, 1.77-10.8), and diabetes mellitus (.26, .09-.63; .24, .08-.63) were independently associated with CMBs.
Conclusions: In patients with ALI, renal dysfunction was positively associated with CMBs independent of cerebral SVD.
2014 | Year | 03 | Month | 29 | Day |
2015 | Year | 09 | Month | 01 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015838
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