Unique ID issued by UMIN | UMIN000014147 |
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Receipt number | R000016474 |
Scientific Title | Comparison of arteriosclerotic indicators in patients with ischemic stroke |
Date of disclosure of the study information | 2014/06/04 |
Last modified on | 2015/03/18 12:26:07 |
Comparison of arteriosclerotic indicators in patients with ischemic stroke
Comparison of arteriosclerotic indicators in patients with ischemic stroke (cross-sectional study)
Comparison of arteriosclerotic indicators in patients with ischemic stroke
Comparison of arteriosclerotic indicators in patients with ischemic stroke (cross-sectional study)
Japan |
Cerebrovascular diseases
Medicine in general | Neurology | Geriatrics |
Adult |
Others
NO
To compare the arteriosclerotic indicators in patients with ischemic stroke: ankle-brachial index, brachial-ankle pulse wave velocity, and cardio-ankle vascular index
Others
Ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and cardio-ankle vascular index (CAVI) are surrogate markers of arteriosclerosis. However, analyses of these indicators in patients with ischemic stroke still remain unclear.
Confirmatory
Pragmatic
Not applicable
The aim of the present study was to compare ABI, baPWV, and CAVI in patients with ischemic stroke and those without a history of stroke.
Observational
Not applicable |
Not applicable |
Male and Female
October 2003 and September 2011, we consecutively enrolled patients with first-ever ischemic stroke admitted to the Hyogo Brain and Heart Center at Himeji within 48 hours after stroke onset.
Patients were excluded if following were present: (1) recurrent stroke, (2) stroke of cardioembolism with either high or medium risk potential cardiac sources of embolism based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, (3) stroke of other determined etiology based on the TOAST classification, (4) ABI <0.9.
800
1st name | |
Middle name | |
Last name | Naoki Saji |
Hyogo Brain and Heart Center at Himeji (Kawasaki Medical School)
Department of Neurology (Department of Stroke Medicine)
520 Saisho-ko, Himeji, Hyogo 670-0981, Japan (577 Matsushima, Kurashiki, Okayama 701-0192, Japan)
079-293-3131
sajink@nifty.com
1st name | |
Middle name | |
Last name | Naoki Saji |
Kawasaki Medical School
Department of Stroke Medicine
577 Matsushima, Kurashiki, Okayama 701-0192, Japan
086-462-1111
sajink@nifty.com
Department of Neurology, Hyogo Brain and Heart Center at Himeji (Department of Stroke Medicine, Kawasaki Medical School)
The KAWASAKI Foundation for Medical Science & Medical Welfare.
Self funding
NO
2014 | Year | 06 | Month | 04 | Day |
Published
http://www.nature.com/hr/journal/vaop/ncurrent/full/hr20158a.html
Between October 2003 and September 2011, we consecutively enrolled patients with stroke presenting with large infarcts (diameter more than 1.5cm) attribute to large artery atherosclerosis (LAA) or lacunar infarcts (diameter less than 1.5cm) attribute to small artery disease (SAD). Outpatients without a history stroke were recruited as a control group (CTL). We divided the study period into two terms and assessed recruited patients using two oscillometric devises respectively in each term. Concretely, ABI and baPWV were measured using Form PWV/ABI during the former term. ABI and CAVI were measured using VaSera VS-1500 during the latter term.
A total of 1380 patients with acute ischemic stroke admitted to the Hyogo Brain and Heart Center at Himeji within 48 hours after stroke onset during the study period. Among them, we excluded 488 patients with cardioembolism and 384 patients with other determined etiology. Of 508 remaining patients, we excluded 126 patients; 69 recurrent stroke, 39 lack of data, and 18 having ABI <0.9. Hence, 382 patients with first-ever ischemic stroke consisting of 280 as SAD and 102 as LAA were enrolled. As a control group (CTL), 460 outpatients consisting of 240 recruited in the first period and 220 recruited in the second period were also enrolled in this study. Finally, we analyzed 842 patients.
Completed
2003 | Year | 10 | Month | 01 | Day |
2003 | Year | 10 | Month | 01 | Day |
2014 | Year | 03 | Month | 31 | Day |
2014 | Year | 03 | Month | 31 | Day |
2014 | Year | 04 | Month | 30 | Day |
2014 | Year | 05 | Month | 31 | Day |
For further details, please see the article.
2014 | Year | 06 | Month | 03 | Day |
2015 | Year | 03 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000016474
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