Unique ID issued by UMIN | UMIN000014315 |
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Receipt number | R000016666 |
Scientific Title | Molecular mechanism of quercetin to regulate amyloid-beta production in Alzheimer's disease |
Date of disclosure of the study information | 2014/07/18 |
Last modified on | 2017/06/21 13:22:29 |
Molecular mechanism of quercetin to regulate amyloid-beta production in Alzheimer's disease
Analysis of the effect of quercetin-containing onion for cognitive function and dysfunction
Molecular mechanism of quercetin to regulate amyloid-beta production in Alzheimer's disease
Analysis of the effect of quercetin-containing onion for cognitive function and dysfunction
Japan |
Alzheimer's disease
Neurology |
Others
NO
Analysis of the effect of quercetin-containing onion to cognitive impairment and Alzheimer's disease
Safety,Efficacy
The effect of quercetin-containing onion is analyzed by interventional trial to patient of mild cognitive impairment and Alzheimer's disease
Interventional
Cross-over
Non-randomized
Single blind -participants are blinded
Placebo
2
Treatment
Food |
Onion powder (quercetin high amount or low amount) 18g are taken every day for four weeks. Washout is for four weeks between each onion powder. The effect is analyzed by cognitive function (HDS-R, MMSE), general physical examination, neurological examination, and blood and urinary test.
Patients who may improve cognitive function after onion powder containing high amount of quercetin is taken for four weeks continue to eat onion powder for twelve months.
Not applicable |
Not applicable |
Male and Female
mild cognitive impairment
Alzheimer's disease
severe cognitive impairment
person cannot eat onion powder every day for four months
30
1st name | |
Middle name | |
Last name | Toshiyuki Nakagawa |
Gifu university
Graduate School of Medicine
1-1 Yanagido, Gifu
058-230-6481
tnakagaw@gifu-u.ac.jp
1st name | |
Middle name | |
Last name | Toshiyuki Nakagawa |
Gifu university
Graduate School of Medicine
1-1 Yanagido, Gifu
058-230-6481
tnakagaw@gifu-u.ac.jp
National Agriculture and Food Research Organization
National Agriculture and Food Research Organization
Japanese Governmental office
NO
2014 | Year | 07 | Month | 18 | Day |
Published
http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2016&issue=06300&article=00008&typ
The present study examined whether memory recall was affected by the intake of quercetin-rich onion (a new cultivar of hybrid onion Quergold) powder in early-stage AD patients. Memory recall in early-stage AD patients, determined using the Revised Hasegawa Dementia Scale, was significantly improved by the intake of quercetin-rich onion (Quergold) powder for 4 weeks compared with the intake of control onion (Mashiro white onion) powder. These results indicate that quercetin might influence memory recall.
Completed
2011 | Year | 04 | Month | 01 | Day |
2011 | Year | 04 | Month | 01 | Day |
2014 | Year | 06 | Month | 19 | Day |
2017 | Year | 06 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000016666
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