Unique ID issued by UMIN | UMIN000014372 |
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Receipt number | R000016726 |
Scientific Title | The difference of combination therapy in uncontrolled hypertension |
Date of disclosure of the study information | 2014/07/01 |
Last modified on | 2017/05/30 14:14:31 |
The difference of combination therapy in uncontrolled hypertension
The difference of combination therapy in uncontrolled hypertension
The difference of combination therapy in uncontrolled hypertension
The difference of combination therapy in uncontrolled hypertension
Japan |
Hypertension
Cardiology |
Others
NO
The aim of this study is to investigate the difference in blood pressure control and some indices between the combination angiotensin receptor blocker (ARB) with calcium blocker and the combination ARB with diuretics in uncontrolled hypertension
Efficacy
Not applicable
-change in blood pressure at home blood pressure measurement
-change in augmentation index
-change in blood pressure (BP) at 24hr BP monitoring and clinic BP
-change in NTproBNP, hsCRP, hsTnT, cystatin C, VEGF-C, LDL cholesterol, triglyceride, HDL cholesterol, BUN, creatinine, potassium, sodium, glucose, urine-sodium, and urinary albumin creatinine ratio
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
NO
NO
Central registration
2
Treatment
Medicine |
One group taken the combination ARB with diuretics (Ecard HD(R))
One group taken the combination ARB with diuretics (Unisia HD(R))
20 | years-old | <= |
Not applicable |
Male and Female
Patients with diagnosed hypertension in our hospital and collaborate research institutes.
(Inclusion criteria)
1)Patients taken each calcium blocker or ARB, or patients with alfa blocker or beta blocker adding in each calcium blocker or ARB.
2)In spite of performing life modification (diet and exercise) and the above medication, their clinic BP is above 140/90mmHg.
(Exclusion criteria)
1)Allergy of these drugs in this study
2)Anuria or hemodialysis
3)Acute renal failure
4)Significant low sodium and potassium
5)Pregnancy or possibility of pregnancy
6)Not given informed consent (adolescents, dementia)
7)In case the physicians decide to be inappropriate in this study
200
1st name | |
Middle name | |
Last name | Kazuomi Kario |
Jichi Medical University School of Medicine
Division of Cardiovascular Medicine, Department of Medicine
3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, JAPAN
0285-58-7538
kkario@jichi.ac.jp
1st name | |
Middle name | |
Last name | Satoshi Hoshide |
Jichi Medical University School of Medicine
Division of Cardiovascular Medicine, Department of Medicine
3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, JAPAN
0285-58-7344
hoshide@jichi.ac.jp
Jichi Medical University School of Medicine
Jichi Medical University School of Medicine
Self funding
Japan
NO
鷲谷病院(栃木県)(Washiya hospital)
国際医療福祉大学病院(栃木県)(International university of health and welfare hospital)
古河赤十字病院(茨城県)(Koga red cross hospital)
2014 | Year | 07 | Month | 01 | Day |
Unpublished
Completed
2011 | Year | 03 | Month | 04 | Day |
2011 | Year | 10 | Month | 25 | Day |
2014 | Year | 06 | Month | 25 | Day |
2017 | Year | 05 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000016726
Research Plan | |
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