Unique ID issued by UMIN | UMIN000014594 |
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Receipt number | R000016979 |
Scientific Title | Optimization of the scan timing after Gd contrast media injection in the detection of brain metastases-Multicenter study- |
Date of disclosure of the study information | 2014/09/01 |
Last modified on | 2021/07/23 11:37:22 |
Optimization of the scan timing after Gd contrast media injection in the detection of brain metastases-Multicenter study-
The optimal interval after Gd injection for MRI of brain metastases
Optimization of the scan timing after Gd contrast media injection in the detection of brain metastases-Multicenter study-
The optimal interval after Gd injection for MRI of brain metastases
Japan |
Brain metastases
Radiology | Neurosurgery |
Malignancy
NO
To investigate the optimal timing of image acquisition for the detection of lesions by retrospectively reviewing contrast-enhanced MRI images of metastatic brain tumors and by assessing changes in the lesion detection rate and in the signal intensity ratio against the surrounding brain parenchyma in function of the latency time between injection and imaging.
Efficacy
Phase IV
The detection rate of metastatic brain tumor by subjective evaluation of images
The signal intensity ratio of metastatic brain tumor against the surrounding brain parenchyma
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients who meet all the following criteria can be included in the study
1) Patients who had undergone Gd-enhanced brain MRI in the past 3 years (dose: 0.1 mmol/kg)
2) Patients who had undergone contrast-enhanced T1-weighted SE images more than once
3) The time between injection of contrast agent and imaging can be estimated by minutes
4) Lesion size: 3 to 20 mm
5) Both inpatient and outpatient
6) Aged 20 years or older
Patients who meet any of the following criteria are not eligible for the study
1) Patients with bleeding that may affect measurement of the signal intensity
2) The signal intensity cannot be measured
3) Patients with 10 or more lesions
4) Patients who have already enrolled in the present study
600
1st name | Aoki |
Middle name | |
Last name | Shigeki |
Juntendo University Hospital
Department of Radiology
113-8421
2-1-1 Hongo, Bunkyo-ku, Tokyo
03-5802-1230
saoki@juntendo.ac.jp
1st name | Kouhei |
Middle name | |
Last name | Kamiya |
The University of Tokyo Hospital
Department of Radiology
113-8655
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655
03-5800-8666
kkamiya-tky@umin.ac.jp
Juntendo University
Bayer Yakuhin, Ltd.
Profit organization
Juntendo University Hospital
113-8421 2-1-1 Hongo, Bunkyo-ku, Tokyo
03-5802-1230
saoki@juntendo.ac.jp
NO
2014 | Year | 09 | Month | 01 | Day |
https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000016979
Published
http://jsmrm2020.umin.jp/program_04.pdf
490
In total, MR images from 490 patients were analyzed (1223 tumor nodules). The detection rate of lesions with diameter of 3-10 mm increased with the delay time, and reached to a plateau around 97.5% at the delay time of 8-10 minutes. Quantitative measure of lesion contrast did not reveal any significant dependence on the delay time.
2021 | Year | 07 | Month | 23 | Day |
patients diagnosed with metastatic brain tumors and underwent contrast-enhanced brain MRI
Retrospective observational study.
Each participating institution registers case records that satisfy the following inclusion criteria; 1) clinically diagnosed as metastatic brain tumor, 2) contrast-enhanced MRI using standard dose of GBCA (0.1 mmol/kg) was acquired, 3) more than two series of 2D-SE T1-weighted images were acquired after GBCA administration, 4) the delay time between image acquisition and GBCA injection could be specified, 5) lesion diameters were within 3-20 mm, 6) over 20 years of age.
None
The detection rate of metastatic brain tumor by subjective evaluation of images
The signal intensity ratio of metastatic brain tumor against the surrounding brain parenchyma
Completed
2014 | Year | 07 | Month | 08 | Day |
2014 | Year | 05 | Month | 23 | Day |
2014 | Year | 09 | Month | 01 | Day |
2019 | Year | 12 | Month | 31 | Day |
Retrospective observation study
2014 | Year | 07 | Month | 18 | Day |
2021 | Year | 07 | Month | 23 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000016979
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