Unique ID issued by UMIN | UMIN000014667 |
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Receipt number | R000017037 |
Scientific Title | Efficiency of hydroxyethyl starch on circulatory dynamics in major abdominal surgery of hepatobiliary or pancreas system compared with using vasoconstrictive agents |
Date of disclosure of the study information | 2014/07/31 |
Last modified on | 2014/07/27 22:19:15 |
Efficiency of hydroxyethyl starch on circulatory dynamics in major abdominal surgery of hepatobiliary or pancreas system compared with using vasoconstrictive agents
Efficiency of hydroxyethyl starch on circulatory dynamics in major upper abdominal surgery
Efficiency of hydroxyethyl starch on circulatory dynamics in major abdominal surgery of hepatobiliary or pancreas system compared with using vasoconstrictive agents
Efficiency of hydroxyethyl starch on circulatory dynamics in major upper abdominal surgery
Japan |
surgical patients scheduled for hepatobiliary or pancreas systems
Hepato-biliary-pancreatic surgery | Anesthesiology |
Malignancy
NO
Abdominal surgery of hepatobiliary and pancreas system induces huge stress against surgical patients and fluctuates circulation. To maintain circulatory dynamics during such surgeries, vasoconstrictive drug such as alpha 1 agents or hydroxyethyl starch fluid is usually used. The aim of the present study is to investigate and compare those treatments from the standpoint of oxidative stress.
Safety,Efficacy
Confirmatory
Pragmatic
Not applicable
Oxidative stress is evaluated by measuring 8-OHdG in blood or urine before the start of surgery and the end of surgery. Intraoperative circulatory system is evaluated by esophageal echocardiography.
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Active
2
Treatment
Medicine |
Two anesthetic managements are planned in cancer resection surgery of hepatobiliary or pancreas system. One is that circulation is maintained with the use of vasoconstrictive drugs (control).
The other is that circulation is maintained with the use of hydroxyethly starch fluid.
20 | years-old | <= |
Not applicable |
Male and Female
Patients scheduled for cancer resection of hepatobiliary or pancreas system
Patients with severe esophageal varices, esophageal ulcer or cancer, and problem of opening mouth.
Patients receiving esophageal cancer surgery.
Patients in whom operation method is changed during operation.
100
1st name | |
Middle name | |
Last name | Masahiko Tsuchiya |
Osaka City University Medical School
Department of Anesthesiology
1-5-7 Asahi-machi, Abeno-ku, Osaka, Japan
06-6645-2186
oxymasa@ea.mbn.or.jp
1st name | |
Middle name | |
Last name | Masahiko Tsuchiya |
Osaka City University Medical School
Department of Anesthesiology
1-5-7 Asahi-machi, Abeno-ku, Osaka, Japan
06-6645-2186
oxymasa@ea.mbn.or.jp
Department of Anesthesiology, Osaka City University Medical School
none
Self funding
NO
2014 | Year | 07 | Month | 31 | Day |
Unpublished
Enrolling by invitation
2014 | Year | 07 | Month | 30 | Day |
2014 | Year | 07 | Month | 30 | Day |
2014 | Year | 07 | Month | 27 | Day |
2014 | Year | 07 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017037
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