Unique ID issued by UMIN | UMIN000014676 |
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Receipt number | R000017069 |
Scientific Title | The deficits in prefrontal cortex functions in depression and the therapeutic efficacy of the attention training technique. |
Date of disclosure of the study information | 2014/08/01 |
Last modified on | 2024/02/28 11:38:39 |
The deficits in prefrontal cortex functions in depression and the therapeutic efficacy of the attention training technique.
The deficits in prefrontal cortex functions in depression and the therapeutic efficacy of the attention training technique.
The deficits in prefrontal cortex functions in depression and the therapeutic efficacy of the attention training technique.
The deficits in prefrontal cortex functions in depression and the therapeutic efficacy of the attention training technique.
Japan |
Major depressive disorder
Psychiatry |
Others
NO
The first aim of this study is to confirm the effect of ATT on alleviating depression symptoms, including rumination, and its effectiveness on preventing the recurrence of depression. The second aim is to reveal the functional deficits of the prefrontal cortex in depression, and to verify how much that could be improved by practicing ATT.
Efficacy
The Hamilton Rating Scale for Depression
Beck Depression Inventory
Montgomery-Asberg Depression Rating Scale
Meta-cognitions Questionnaire-30
Detached Mindfulness Mode Questionnaire
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Educational,Counseling,Training
Behavior,custom |
Intervention of the ATT( attention training technique) is usually performed for 8 weeks in treatment.
16 | years-old | <= |
Not applicable |
Male and Female
Those who were diagnosed as major depression disorder using the Structured Clinical Interviews for DSM-5(SCID-1).
Atypical features, bipolar disorders, psychotic disorders, substance-related disorders, personality disorders, comorbid with or having any history of dementia, dosing tricyclic antidepressant drugs
40
1st name | Takamasa |
Middle name | |
Last name | Noda |
National Center Hospital, National Center of Neurology and Psychiatry
Department of Psychiatry
187-8551
1-1-4 Ogawa-Higashi-Cho, Kodaira-Shi, Tokyo, 187-8551
0423412711
t-noda@ncnp.go.jp
1st name | Shiori |
Middle name | |
Last name | Setoyama |
National Center Hospital, National Center of Neurology and Psychiatry
Department of Psychiatry
187-8551
1-1-4 Ogawa-Higashi-Cho, Kodaira-Shi, Tokyo, 187-8551
042-341-2711
nodat_labo@ncnp.go.jp
Faculty of HumanSciences, WASEDA University
Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP
Other
Institutional Review Board, National Center of Neurology and Psychiatry
1-1-4 Ogawa-Higashi-Cho, Kodaira-Shi, Tokyo, 187-8551
042-341-2711
irb-office@ncnp.go.jp
NO
国立研究開発法人国立精神・神経医療研究センター病院(東京都)
2014 | Year | 08 | Month | 01 | Day |
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000017069
Unpublished
https://kaken.nii.ac.jp/file/KAKENHI-PROJECT-25461790/25461790seika.pdf
42
Tests on healthy subjects indicated attentional function training might enhance attentional control and alleviate depression. Subsequently, ATT was applied for 7 weeks on 10 major depression patients, reducing negative rumination, anxiety, and enhancing divided attention. Depressive symptoms decreased, and "distanced attentiveness" (DM) improved. Brain function indicators revealed increased cerebral blood flow in specific regions correlated with enhanced attention control.
2024 | Year | 02 | Month | 28 | Day |
Subjects were patients with major depressive disorder and healthy subjects aged 16 years and older.
The patient group was diagnosed using the Psychiatric Diagnostic Interview (SCID).
[Exclusion criteria]
Things with atypical characteristics
Those with comorbidity or history of bipolar disorder, psychotic disorder, substance-related disorder, personality disorder, or dementia
Taking tricyclic antidepressants
[Cancellation criteria]
If the patient group worsens by two or more levels on the CGI-S during the intervention period, the intervention will be discontinued.
If healthy subjects become unwell, the intervention will be discontinued at the discretion of a physician.
Of the 42 patients who consented to participate in the study, 16 patients in the patient group and 26 in the healthy group participated in the study. The patient group participated in an open study, and all patients were in the intervention group. The healthy subjects participated in the RCT study, with 13 patients in the intervention group and 13 patients in the control group. In the patient group, 2 patients dropped out and 4 patients had unanalyzable data, so the analysis target population was 10 patients. The analysis target population of the healthy group was 26 cases.
None
[Biological indicators]
Cerebral blood flow test using optical topography device (NIRS)
Word fluency task (VFT) and dichotic listening task (DLT)
Magnetic resonance imaging (MRI)
3D structural images, resting brain activity, flare images, DTI, ASL
[Psychiatric symptom evaluation]
Hamilton Depression Rating Scale (HAM-D/HDS)
Young Mania Rating Scale Japanese version (YMRS-J)
Montgomery Asberg Depression Rating Scale (MADRS)
Japanese version of Beck Depression Questionnaire 2nd edition (BDI-2)
State/Trait Anxiety Test (STAI-S, T)
[Cognitive/attention function evaluation]
Attention control function measurement scale
Negative rumination scale
Japanese version of MCQ (scale to measure metacognitive beliefs)
DMMQ (scale to measure detached mindfulness)
Completed
2014 | Year | 06 | Month | 27 | Day |
2012 | Year | 06 | Month | 04 | Day |
2014 | Year | 08 | Month | 12 | Day |
2016 | Year | 06 | Month | 24 | Day |
2014 | Year | 07 | Month | 28 | Day |
2024 | Year | 02 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017069
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