Unique ID issued by UMIN | UMIN000014717 |
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Receipt number | R000017106 |
Scientific Title | Investigation for the relationships between treatment resistant psychiatric patients and anti-NMDA receptor antibody encephalitis. |
Date of disclosure of the study information | 2014/08/01 |
Last modified on | 2020/08/04 12:13:28 |
Investigation for the relationships between treatment resistant psychiatric patients and anti-NMDA receptor antibody encephalitis.
Investigation for the relationships between treatment resistant psychiatric patients and anti-NMDA receptor antibody encephalitis.
Investigation for the relationships between treatment resistant psychiatric patients and anti-NMDA receptor antibody encephalitis.
Investigation for the relationships between treatment resistant psychiatric patients and anti-NMDA receptor antibody encephalitis.
Japan |
Treatment resistant psychiatric disease, anti-NMDA receptor antibody encephalitis
Neurology | Clinical immunology | Psychiatry |
Others
NO
We investigate the antibody titers of anti-NMDA receptor antibody in patients with treatment resistant psychiatric disease. We evaluate the correlation between those and the clinical symptoms, clinical diagnosis, the results of laboratory and imaging examination.
Others
Clinical utility
Exploratory
Pragmatic
Not applicable
Demographic information of the targets are age, gender, psychiatric symptoms, disease duration and psychiatric diagnosis.
Clinical symptoms include disturbance of consciousness, convulsions, disorientation, impaired short-term memory, anarithmia, configuration failure, hallucinations, delusions, anxiety, depression, emotional lability, personality change, gait disturbance, bradykinesia, muscular rigidity, tremor and Katatonia.
Blood tests include general blood tests, autoantibodies such as TG and TPO antibodies and thyroid function tests (TSH fT3 fT4). Anti-neuronal antibodies are anti-NMDA-NR1 and NR2 antibody.
Cerebrospinal fluid tests includes general examination, anti-NMDA-NR1 and NR2 antibody.
Imaging and physiological function tests are head MRI examination, head SPECT and EEG.
Psychological tests are cognitive function test such as WAIS-III, WMS-R, WCST, MMSE, and HDS-R. Psychiatric evaluation includes PANSS and BPRS. (We use the data that is listed in the medical record)
For the normal volunteer, we perform blood tests, head MRI examination and psychological examination. Cerebrospinal fluid examination is performed when the consent was obtained from the volunteer.
Correlation between the titer of the anti-NMDA receptor antibodies and the clinical symptoms, clinical diagnosis, the results of laboratory and imaging examination.
Observational
Not applicable |
Not applicable |
Male and Female
Psychiatric patients who did not remitted by the standard more than 2 medications.
Normal controls are healthy volunteers.
Psychiatric patients who were treated by less than 1 standard psychiatric medication.
100
1st name | Yuhei |
Middle name | |
Last name | Chiba |
Yokohama city university hospital
Department of psychiatry
236-0004
3-9, Fukuura, kanazawa-ku, Yokohama-shi
045-787-2800
suezan_2000@yahoo.co.jp
1st name | Yuhei |
Middle name | |
Last name | Chiba |
Yokohama city university hospital
Department of psychiatry
236-0004
3-9, Fukuura, kanazawa-ku, Yokohama-shi
045-787-2800
yu_chiba@yokohama-cu.ac.jp
Yokohama city university hospital
Grants-in-Aid for Scientific Research
Japanese Governmental office
Japan
Yokohama City university Hospital
Fukuura 3-9, Kanazawa-ku, Yokohama-shi, Japan
+81-45-787-2800
rinri@yokohama-cu.ac.jp
NO
2014 | Year | 08 | Month | 01 | Day |
Unpublished
Enrolling by invitation
2014 | Year | 07 | Month | 04 | Day |
2014 | Year | 08 | Month | 01 | Day |
2014 | Year | 08 | Month | 01 | Day |
2024 | Year | 07 | Month | 31 | Day |
We investigate the antibody titers of anti-NMDA receptor antibody in the serum and CSF of patients with treatment resistant psychiatric disease. We evaluate the correlation between those and the clinical symptoms, clinical diagnosis, the results of laboratory and imaging examination. This study is a open labeled and prospective study.
Invasiveness examinations are blood collection and cerebrospinal fluid collection.
For the volunteers, cerebrospinal fluid collection is performed when the consent was obtained.
2014 | Year | 07 | Month | 31 | Day |
2020 | Year | 08 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017106
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