Unique ID issued by UMIN | UMIN000015423 |
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Receipt number | R000017915 |
Scientific Title | The prevention of Alzheimer's disease through regulation of amyloid beta synthesis and brake-down by propolis intake |
Date of disclosure of the study information | 2014/10/14 |
Last modified on | 2018/10/20 14:17:09 |
The prevention of Alzheimer's disease through regulation of amyloid beta synthesis and brake-down by propolis intake
The prevention of Alzheimer's disease by propolis intake
The prevention of Alzheimer's disease through regulation of amyloid beta synthesis and brake-down by propolis intake
The prevention of Alzheimer's disease by propolis intake
Japan |
type 2 diabetes
dementia
Endocrinology and Metabolism |
Others
NO
The aim of this study is to examine the effects of Propolis for prevention of Alzheimer's disease through regulation of amyloid beta synthesis and brake-down in patients with type 2 diabetes
Efficacy
amyloid-beta, Tau protein, activity of the beta-amyloid converting enzyme 1
HbA1c, fasting plasma glucose, serum insulin, Mini-Mental State Examination
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
NO
NO
NO
Numbered container method
2
Prevention
Food |
Brazilian Propolis(450.0mg/day)
placebo
60 | years-old | <= |
85 | years-old | > |
Male and Female
1) Patients who are able to give written informed consent
2) Age is over 60 years and less than 85 years
3) MMSE score 24-27.
4) HbA1c 6.0-10.0%
5) Patients are able to do the following things in this trial - getting good compliance with consuming investigational food and coming to hospital
1) Patients who did not agree with this study
2) Patients with severe renal dysfunction and severe hepatic dysfunction
3) Type 1 diabetes and other specific types of diabetes resulting from specific genetic syndromes, surgery, drugs, malnutrition, infections, and other illnesses
4) Patients treated with insulin
5) Patients with dementia or neurodegenerating disease
6) Patients who is taking drugs which affect
the cognitive function
7) Patients who changed oral hypoglycemic drugs significantly
8) Patients who changed drugs which affect pH of interstitial fluid
9) Patients judged by the investigator to be ineligible for some other reason
60
1st name | |
Middle name | |
Last name | Yoshinori Marunaka |
Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Department of Molecular Cell Physiology
465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566 Japan
+81-75-251-5311
marunaka@koto.kpu-m.ac.jp
1st name | |
Middle name | |
Last name | Shinobu Matsumoto |
Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Department of Endocrinology and Metabolism
465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566 Japan
+81-75-251-5506
s-matsu3@koto.kpu-m.ac.jp
Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Yamada Apiculture Center Inc. (Okayama, Japan)
Profit organization
NO
京都府立医科大学附属病院(京都府)
2014 | Year | 10 | Month | 14 | Day |
Unpublished
Terminated
2014 | Year | 06 | Month | 25 | Day |
2014 | Year | 11 | Month | 01 | Day |
2018 | Year | 02 | Month | 10 | Day |
2014 | Year | 10 | Month | 13 | Day |
2018 | Year | 10 | Month | 20 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017915
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