Unique ID issued by UMIN | UMIN000015440 |
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Receipt number | R000017925 |
Scientific Title | Plasma exchange with mPSL-PULSE therapy against Isaacs' syndrome |
Date of disclosure of the study information | 2014/10/15 |
Last modified on | 2014/10/15 19:22:18 |
Plasma exchange with mPSL-PULSE therapy against Isaacs' syndrome
Plasma exchange with mPSL-PULSE therapy against Isaacs' syndrome
Plasma exchange with mPSL-PULSE therapy against Isaacs' syndrome
Plasma exchange with mPSL-PULSE therapy against Isaacs' syndrome
Japan |
Isaacs' syndrome
Neurology |
Others
NO
In a patient whose symptoms are debilitating or refractory to anticonvulsant therapy, neuromyotonia improves and remits with this treatment
Safety,Efficacy
MG-ADL score
modified Rankin scale
myotonia score
%VC
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine | Device,equipment |
The set therapy consists of 1 plasmapheresis followed by mPSL-PULSE, which is performed by serial intravenous injection of 1.0 g methylprednisolone immediately after plasmapheresis and on the morning of the subsequent 2 days. A patient is admitted to our hospitals for the set therapy, and the set is administered and repeated during the hospitalization to improve the patient's symptoms. Plasmapheresis is performed using the plasma-exchange method. The set therapy during hospitalization can also consist of oral prednisolone not exceeding 20 mg/day in addition to mPSL-PULSE. After completing the set therapy and discharge from the hospital, the patient is followed up and treated as needed to maintain. If symptoms deteriorate again or prednisolone >10 mg/day is needed, the patient is recommended to be hospitalized
and undergo the set therapy again.
20 | years-old | <= |
Not applicable |
Male and Female
Patient is applicable to definite or probable of provisional diagnostic criteria for Isaacs' syndrome (Watanabe, Clinical Neurology 2013;53:1067-1070).
Severe infection.
1
1st name | |
Middle name | |
Last name | Takanari Toyoda |
Nagoya City University Graduate School of Medical Sciences
Neurology
1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi
052-853-8094
ttoyoda@med.nagoya-cu.ac.jp
1st name | |
Middle name | |
Last name | Takanari Toyoda |
Nagoya City University Graduate School of Medical Sciences
Neurology
1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi
052-851-5511
http://www.med.nagoya-cu.ac.jp/cr.dir/patient/f_patient.html
ttoyoda@med.nagoya-cu.ac.jp
Department of Neurology, Nagoya City University Graduate School of Medical Sciences
None
Self funding
NO
2014 | Year | 10 | Month | 15 | Day |
Unpublished
No longer recruiting
2014 | Year | 09 | Month | 19 | Day |
2014 | Year | 10 | Month | 15 | Day |
2017 | Year | 09 | Month | 30 | Day |
2014 | Year | 10 | Month | 15 | Day |
2014 | Year | 10 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017925
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