Unique ID issued by UMIN | UMIN000016190 |
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Receipt number | R000018789 |
Scientific Title | Association between plasma pentraxin-3 levels and risk of all-cause mortality in Japanese hemodialysis patients with nutritional risk |
Date of disclosure of the study information | 2015/02/01 |
Last modified on | 2020/01/20 07:26:43 |
Association between plasma pentraxin-3 levels and risk of all-cause mortality in Japanese hemodialysis patients with nutritional risk
PTX3 in protein energy wasting
Association between plasma pentraxin-3 levels and risk of all-cause mortality in Japanese hemodialysis patients with nutritional risk
PTX3 in protein energy wasting
Japan |
End stage kidney disease
Nephrology |
Others
NO
Persistent inflammation is an important cause of protein-energy wasting, which is a potent predictor of mortality. Therefore, regular monitoring of inflammatory biomarkers may be clinically useful for estimating mortality risk in dialysis patients. Pentraxin-3 (PTX3), a new candidate marker for inflammation, belongs to the same pentraxin superfamily of acute-phase reactants as C-reactive protein (CRP). PTX3 has been reported to be associated with all-cause mortality in Caucasian patients with end-stage kidney disease. However, uncertainty remains regarding PTX3 in relation to nutritional status, and no data are available on PTX3 in Asian hemodialysis patients.
Others
biomarker research
Exploratory
Explanatory
Not applicable
All-cause mortality
Nutritional status
Cardiovascular mortality
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Maintenance hemodialysis patietnt
Age < 20 years old
The patient who judged to be inappropriate for the study by attending physician.
300
1st name | Tetsu |
Middle name | |
Last name | TMiyamoto |
University of Occupational and Environmental Health
Second Department of Internal Medicine
807-8555
Iseigaoka 1-1, Yahatanishi, Kitakyushu, Fukuoka
093-603-1611
tetsum@med.uoeh-u.ac.jp
1st name | Tetsu |
Middle name | |
Last name | Miyamoto |
University of Occupational and Environmental Health
Second Department of Internal Medicine
807-8555
Second Department of Internal Medicine
093-603-1611
tetsum@med.uoeh-u.ac.jp
Second Department of Internal Medicine, University of Occupational and Environmental Health
Grant-in-Aid for Scientific Research (KAKENHI)
Non profit foundation
University of Occupational and Environmental Health
Iseigaoka 1-1, Yahatanishii, Kitakyushu
+81936031611
tetsum@med.uoeh-u.ac.jp
NO
2015 | Year | 02 | Month | 01 | Day |
Unpublished
383
No longer recruiting
2011 | Year | 08 | Month | 01 | Day |
2011 | Year | 08 | Month | 03 | Day |
2011 | Year | 09 | Month | 01 | Day |
2018 | Year | 08 | Month | 31 | Day |
From Aug of 2011, 380 maintenance hemodialysis patients (38% female; median age, 66 years; age range, 21-92 years) were recruited. We are investigating the effect of plasma PTX3 levels, measured by enzyme-linked immunosorbent assay, on all-cause mortality, with a particular focus on nutritional risk.
2015 | Year | 01 | Month | 12 | Day |
2020 | Year | 01 | Month | 20 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018789
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