Unique ID issued by UMIN | UMIN000016448 |
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Receipt number | R000019106 |
Scientific Title | The effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system |
Date of disclosure of the study information | 2015/02/05 |
Last modified on | 2020/10/29 16:24:07 |
The effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system
The effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system
The effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system
The effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system
Japan |
Pediatric patients undergoing an electrophysiologic study and the radiofrequency catheter ablation
Cardiology | Pediatrics | Anesthesiology |
Child |
Others
NO
The purpose of this study is to investigate dose-dependent effects of propofol on the cardiac conduction system and the cardiac autonomic nervous system.
Pharmacodynamics
sinus node recovery time
sinoatrial conduction time
atrial-His intervals
His-ventricular intervals
heart rate valiability analysis
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Treatment
Medicine |
After continuous propofol infusion at a rate of 5mg/kg/h,2mg/kg of propofol is injected,followed by continuous infusion of propofol at a rate of 10mg/kg/h for 10min
3 | years-old | <= |
15 | years-old | >= |
Male and Female
ASA physical status 1 and 2 pediatric patients who were scheduled undergoing
electrophysiologic study and radiofrequency catheter ablation for tachyarrhythmia
Patients with allergy to propofol and
its solvents
Patients with severe heart diseases
Patients with liver dysfunction
Patients with renal dysfunction
50
1st name | Mayuka |
Middle name | |
Last name | Matsushima |
Kinki University Hospital,Faculty of
Medicine
Central operation department
5898511
377-2 Oono-higashi,Oosakasayama City,Oosaka,Japan
072-366-0221
m-shiba@med.kindai.ac.jp
1st name | Mayuka |
Middle name | |
Last name | Matsushima |
Kinki University Faculty of Medicine
Deparment of Anesthesiology
5898511
377-2 Oono-higashi,Oosakasayama City,Oosaka,Japan
072-366-0221
m-shiba@med.kindai.ac.jp
Deparment of Anesthesiology Kinki University Faculty of Medicine
Deparment of Anesthesiology Kinki University Faculty of Medicine
Self funding
Ethics Committee of Kindai University Faculty of Medicine
377-2 Oono-higashi,Oosakasayama City,Oosaka,Japan
072-366-0221
gakumu@med.kindai.ac.jp
NO
近畿大学医学部附属病院
2015 | Year | 02 | Month | 05 | Day |
https://doi.org/10.1111/jcpt.13302
Published
https://doi.org/10.1111/jcpt.13302
23
Results and discussion
Propofol significantly suppressed intrinsic cardiac HV conduction, but did not affect the SNRT, SACT or the AH interval. As HV blocks, which occur below the His bundle, are often life-threatening, the HV conduction delay may be a cause of severe AV blocks induced by propofol. Propofol directly suppressed parasympathetic nerve activity, and sympathetic nerve activity was also suppressed.
2020 | Year | 10 | Month | 29 | Day |
2020 | Year | 10 | Month | 24 | Day |
Twenty-three patients (age: 6-15 years; males: 16, females: 7) who were scheduled to undergo radiofrequency catheter ablation (RFCA) were prospectively enrolled in this study.
All of the patients had physical statuses of I or II according to the American Society of Anesthesiologists classification and apart from their cardiac arrhythmias were otherwise healthy
written informed consent from the parents of the patients.
The administration of all anti-arrhythmia drugs was stopped 2 days before the RFCA. The patients did not receive any premedication.
none
sinus node recovery time
sinoatrial conduction time
atrial-His intervals
His-ventricular intervals
heart rate valiability analysis
Completed
2014 | Year | 08 | Month | 11 | Day |
2014 | Year | 08 | Month | 11 | Day |
2014 | Year | 09 | Month | 08 | Day |
2019 | Year | 03 | Month | 08 | Day |
2019 | Year | 03 | Month | 08 | Day |
2019 | Year | 03 | Month | 08 | Day |
2019 | Year | 03 | Month | 08 | Day |
2015 | Year | 02 | Month | 05 | Day |
2020 | Year | 10 | Month | 29 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019106
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