Unique ID issued by UMIN | UMIN000016485 |
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Receipt number | R000019141 |
Scientific Title | Pilot study about imaging method of 18F-fluoro-dopa and 11C-raclopride in Parkinson's disease and Parkinson's syndrome |
Date of disclosure of the study information | 2015/02/09 |
Last modified on | 2018/01/24 09:39:06 |
Pilot study about imaging method of 18F-fluoro-dopa and 11C-raclopride in Parkinson's disease and Parkinson's syndrome
PD-1
Pilot study about imaging method of 18F-fluoro-dopa and 11C-raclopride in Parkinson's disease and Parkinson's syndrome
PD-1
Japan |
Healthy subjects, Parkinson's disease patients and Parkinson's syndrome patients
Neurology | Radiology |
Others
NO
Basic data acquisition of PET image of 18F- fluoro-dopa and 11C- raclopride in healthy subjects, Parkinson's disease patients and Parkinson's syndrome patients
Others
Data acquisition
Integrated ratio of striatum and cerebellum cortex or the occipital lobe
Standard uptake value(SUV) of the striatum
Interventional
Parallel
Non-randomized
Open -no one is blinded
Placebo
2
Diagnosis
Medicine | Device,equipment |
Intravenous injection of 18F-fluoro-dopa and 11C-raclopride
PET imaging
35 | years-old | <= |
Not applicable |
Male and Female
Healthy
over 35 years old
Subjects who do not have clinically abnormal findings in the head MRI
Subjects who informed consent was obtained
Sbjects who do not have healthy problem to participate in clinical research
Parkinson's disease/Parkinson's syndrome
over 35 years old
Sbjects who has been diagnosed with Parkinson's disease or Parkinson's syndrome clinically
Subjects who have normal finding or do not have organic lesions to doubt Parkinson's syndrome associated with the central nervous system degenerative disease in MRI imaging
Subjects who informed consent was obtained
Sbjects who do not have healthy problem to participate in clinical research
Subjects who consciousness is not clear
Subjects with cerebrovascular disorder
Subjects with cardiac dysfunction
Subjects with QT prolongation and ventricular arrhythmias on the electrocardiogram
Subjects with liver and kidney failure
Subjects with gastric ulcer and duodenal ulcer
Subjects with diabetes
Subjects with serious lung disease, bronchial asthma and endocrine disease
Subjects with angle-closure glaucoma and chronic open-angle glaucoma
Subjects who are psychiatric symptoms such as suicidal tendencies
Subjects who are taking non-selective monoamine oxidase inhibitors
Subjects who suffer from the symptomatic parkinsonism by clear organic cause
Subjects who have the history of drug allergy
Subjects who it is difficult to skip Parkinson treatment medicine from the day before
Subjects with rhabdomyolysis
Subjects with malignant syndrome
Subjects with pheochromocytoma
Subjects with prolactin-secreting pituitary tumor
Subjects who are dehydration and malnutrition state
Subjects Who exhibit a strong response to drink
Subjects who are drug dependence, alcohol dependence
Subjects who have participated in clinical research within the past 3 months
Subjects who reserchers judged as inappropriate
20
1st name | |
Middle name | |
Last name | Michio Senda |
Institute of Biomedical Research and Innovation
Division of Molecular Imaging
2-2, Minatojima-Minamimachi, Chuo-ku, Kobe
078-304-5212
senda@fbri.org
1st name | |
Middle name | |
Last name | Akihito Ohnishi |
Institute of Biomedical Research and Innovation
Division of Molecular Imaging
2-2, Minatojima-Minamimachi, Chuo-ku, Kobe
078-304-5212
ohnishi@fbri.org
Institute of Biomedical Research and Innovation
Foundation of Biomedical Research and Innovation
Non profit foundation
NO
先端医療センター(兵庫県)
2015 | Year | 02 | Month | 09 | Day |
Published
Published in Ann Nucl Med 2017; 31:163-171,
Completed
2014 | Year | 12 | Month | 04 | Day |
2015 | Year | 02 | Month | 25 | Day |
2015 | Year | 02 | Month | 09 | Day |
2018 | Year | 01 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019141
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