Unique ID issued by UMIN | UMIN000016572 |
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Receipt number | R000019231 |
Scientific Title | High flow nasal cannula versus venturi mask for cardiovascular surgical patients after endotracheal extubation; A randomized crossover study |
Date of disclosure of the study information | 2015/02/18 |
Last modified on | 2022/03/07 14:05:41 |
High flow nasal cannula versus venturi mask for cardiovascular surgical patients after endotracheal extubation; A randomized crossover study
High flow nasal cannula versus venturi mask for cardiovascular surgical patients after endotracheal extubation
High flow nasal cannula versus venturi mask for cardiovascular surgical patients after endotracheal extubation; A randomized crossover study
High flow nasal cannula versus venturi mask for cardiovascular surgical patients after endotracheal extubation
Japan |
Patients who underwent cardiovascular surgery
Anesthesiology | Intensive care medicine |
Others
NO
The aim of this study is to evaluate efficacy of high flow nasal cannula for cardiovascular surgical patients after extubation compared with venturi mask.
Safety,Efficacy
Arterial blood gas analysis(PaO2,PaCO2,pH,HCO3-)
Physiologic date(respiratory rate, heart rate, blood pressure, cardiac index, mixed venous oxygen saturation)
Interventional
Cross-over
Randomized
Individual
Open -no one is blinded
Active
2
Prevention
Device,equipment |
Protocol A
venturi mask for 30 minutes, venturi mask for one hour,high flow nasal cannula for one hour
Protocol B
venturi mask for 30 minutes,high flow nasal cannula for one hour,venturi mask for one hour
18 | years-old | <= |
Not applicable |
Male and Female
Patients scheduled cardiovascular surgery (valvuar surgery and coronary artery bypass grafting with median sternotomy using cardiopulmonary bypass)
Patients who has obstructive lung disease and chronic renal failure.
Patients who requires more than 24 hours until extubation.
Emergent surgery
40
1st name | Osamu |
Middle name | |
Last name | Umegaki |
Osaka medical college
Department of intensive care unit
5698686
2-7 Daigaku-machi, Takatsuki, Osaka
+81-72-683-1221
swithp2006@yahoo.co.jp
1st name | Shiho |
Middle name | |
Last name | Deguchi |
Osaka medical college
Department of intensive care unit
5698686
2-7 Daigaku-machi, Takatsuki, Osaka
+81-72-683-1221
swithp2006@yahoo.co.jp
Department of intensive care unit
Osaka medical college
Department of intensive care unit
Osaka medical college
Other
Department of intensive care unit Osaka medical college
2-7 Daigaku-machi, Takatsuki, Osaka
072-683-1221
rinri@art.osaka-med.ac.jp
NO
2015 | Year | 02 | Month | 18 | Day |
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000019231
Unpublished
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000019231
40
35 patients were enrolled, and 5 patients were excluded from analysis in accordance with the exit criteria. PFR was significantly higher in the HFNC group than in the VM group [265.9 (81.4) vs. 238.7 (68.5), p=0.002]. PaCO2 was significantly lower in the HFNC group than in the VM group [33.8 (3.5) vs. 34.7 (2.9), p=0.033]. The respiratory rate was significantly lower in the HFNC group than in the VM group [18 (4) vs. 21 (4), p=0.006], and no significant differences were seen in any of the other parameters.
2022 | Year | 03 | Month | 07 | Day |
Forty patients who underwent cardiovascular surgery
40 patients who underwent cardiovascular surgery in 2015 were randomized to either protocol A (HFNC followed by VM) or protocol B (VM followed by HFNC). After 60-minutes of use with either device, arterial blood gas analysis was performed, and the PaO2/FiO2 ratio (PFR) was calculated. Simultaneously, physiological data (respiratory rate, heart rate, mean arterial pressure, continuous cardiac index, and mixed venous oxygen saturation) were recorded. During this procedure, FiO2 and gas flow were maintained at a fixed rate. These variables were compared by using the paired t-test, and a p value < 0.05 was considered significant. All data were expressed as mean (standard deviation).
Nothing
blood gas analysis (PaO2/FiO2 ratio (PFR) ,PaCO2, HCO3-, pH)
physiological data (respiratory rate, heart rate, mean arterial pressure, continuous cardiac index, and mixed venous oxygen saturation)
Open public recruiting
2014 | Year | 12 | Month | 01 | Day |
2014 | Year | 12 | Month | 16 | Day |
2014 | Year | 12 | Month | 16 | Day |
2016 | Year | 06 | Month | 30 | Day |
2015 | Year | 02 | Month | 18 | Day |
2022 | Year | 03 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019231
Research Plan | |
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Registered date | File name |
2022/03/07 | NHFvsVM倫理審査申請書②.doc |
Research case data specifications | |
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Registered date | File name |
2022/03/07 | NHFvsVM説明書②.docx |
Research case data | |
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Registered date | File name |
2022/03/05 | UMIN登録用患者背景(日本語).docx |