Unique ID issued by UMIN | UMIN000017284 |
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Receipt number | R000020055 |
Scientific Title | Pharmacokinetics of Tolvaptan:Influence of portal hypertension |
Date of disclosure of the study information | 2015/04/26 |
Last modified on | 2015/04/26 05:15:38 |
Pharmacokinetics of Tolvaptan:Influence of portal hypertension
Pharmacokinetics of Tolvaptan:Influence of portal hypertension
Pharmacokinetics of Tolvaptan:Influence of portal hypertension
Pharmacokinetics of Tolvaptan:Influence of portal hypertension
Japan |
Decompensated cirrhosis
Hepato-biliary-pancreatic medicine |
Others
NO
To clarify the relationship between the pharmacokinetics of Tolvaptan and portal hypertension.
Pharmacokinetics
the relationship between the pharmacokinetics of Tolvaptan and portal hypertension.
the relationship between the diuretic effect and the pharmacokinetics of Tolvaptan.
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients with ascites due to cirrhosis, poorly reacted by following conventional diuretics. 1)more than 40mg furosemide + more than 25mg spironolactone or 2)more than 20mg furosemide + more than 50mg spironolactone
(1)Hepatic encephalopathy
(2)Hepatocellular carcinoma vascular invasion is observed in hepatic vein trunk, portal vein trunk,or inferior vena cava
(3)NYHA Class 3 or more of heart disease
(4)anuria, urinary tract stenosis, stones, or tumors urinary excretion.
(5)Patients with cerebrovascular disease within 30 days.
(6)Patients with following laboratory values can be seen:Hb<8.0g/dl,T-bil> 4.0mg/dl,Cre>2.0mg/dl,serum Na>147mEq/l,serum K>5.5mEq/l
40
1st name | |
Middle name | |
Last name | Eri Sagawa |
Juntendo University Nerima Hospital
Department of Gastroenterology
3-1-10 Takanodai, Nerima-Ku Tokyo, Japan
03-5923-3111
earai@juntendo.ac.jp
1st name | |
Middle name | |
Last name | Eri Sagawa |
Juntendo University Nerima Hospital
Department of Gastroenterology
3-1-10 Takanodai, Nerima-Ku Tokyo, Japan
03-5923-3111
earai@juntendo.ac.jp
Juntendo University Nerima Hospital
Department of Gastroenterology
Juntendo University Nerima Hospital
Department of Gastroenterology
Self funding
NO
2015 | Year | 04 | Month | 26 | Day |
Unpublished
Preinitiation
2015 | Year | 04 | Month | 07 | Day |
2015 | Year | 04 | Month | 26 | Day |
Evaluation of the relationship between the pharmacokinetics of Tolvaptan and portal hypertension.
2015 | Year | 04 | Month | 26 | Day |
2015 | Year | 04 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020055
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