Unique ID issued by UMIN | UMIN000017507 |
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Receipt number | R000020294 |
Scientific Title | Study on the role of intramyocellular lipid (IMCL) in patients with heart failure (HF) |
Date of disclosure of the study information | 2015/05/11 |
Last modified on | 2015/05/11 20:28:42 |
Study on the role of intramyocellular lipid (IMCL) in patients with heart failure (HF)
HF and IMCL
Study on the role of intramyocellular lipid (IMCL) in patients with heart failure (HF)
HF and IMCL
Japan |
Heart faiulre
Cardiology |
Others
NO
To examine whether IMCL is increased in patients with HF
Others
observational study
IMCL
Observational
20 | years-old | <= |
Not applicable |
Male
HF patients (NYHA I-III) with dilated cardiomyopathy (DCM) with left ventricular ejection fraction (LVEF) less than 40%
1) Patients who had the implanted mechanical devices
2) Patients wiht NYHA IV
3) Patients who could not perform exercise testing
4) Patients with diabetes mellitus (DM)
20
1st name | |
Middle name | |
Last name | Hiroyuki Tsutsui |
Hokkaido University School of Medicine
Cardiovascular Medicine
Kita-15, Nishi-7, Kita-ku, Sapporo
011-706-6973
cvsecret@med.hokudai.ac.jp
1st name | |
Middle name | |
Last name | Shintaro Kinugawa |
Hokkaido University School of Medicine
Cardiovascular Medicine
Kita-15, Nishi-7, Kita-ku, Sapporo
011-706-6973
tuckahoe@med.hokudai.ac.jp
Hokkaido University School of Medicine, Cardiovascular Medicine
The Ministry of Education, Science, and Culture
NO
2015 | Year | 05 | Month | 11 | Day |
Published
Peak oxygen uptake (VO2) and anaerobic threshold were significantly lower in HF compared to control. Maximal phosphocreatine loss assessed by 31P-magnetic resonance spectroscopy (MRS) during unilateral plantar flexion exercise was significantly greater in DCM. IMCL content assessed by 1H-MRS was significantly increased in DCM. There was a significant correlation among peak VO2, maximal phosphocreatine loss, and skeletal muscle IMCL content.
Completed
2007 | Year | 06 | Month | 14 | Day |
2007 | Year | 09 | Month | 18 | Day |
2009 | Year | 10 | Month | 15 | Day |
2009 | Year | 11 | Month | 15 | Day |
2010 | Year | 03 | Month | 30 | Day |
2011 | Year | 06 | Month | 01 | Day |
Energy metabolism in the skeletal muscle and IMCL were measured by using MR spectroscopy, and the association among them was investigated.
2015 | Year | 05 | Month | 11 | Day |
2015 | Year | 05 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020294
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