Unique ID issued by UMIN | UMIN000017987 |
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Receipt number | R000020844 |
Scientific Title | Plasma CRP and life prognosis in Parkinson disease: a retrospective study |
Date of disclosure of the study information | 2015/06/19 |
Last modified on | 2015/07/29 10:50:32 |
Plasma CRP and life prognosis in Parkinson disease: a retrospective study
CRP-survival study
Plasma CRP and life prognosis in Parkinson disease: a retrospective study
CRP-survival study
Japan |
Parkinson disease
Neurology |
Others
NO
To determine the role of baseline CRP levels in prognosis of patients with Parkinson disease (PD).
Others
life prognosis
Others
The primary outcome measure was a survival time from the study enrollment to death.
Observational
Not applicable |
Not applicable |
Male and Female
Consecutive patients with PD who were treated at the Department of Neurology, the National Regional Center for Neurological Disorders and National Hospital of Utano from March 2004 to November 2007 were enrolled, and the medical records were retrospectively reviewed. The diagnosis of PD was based on the United Kingdom Parkinson's disease Brain Bank Diagnostic Criteria. The inclusion enrolment criteria included PD patients free of any infection who underwent measurement of plasma CRP.
Patients with any infections at 28 days around the blood sampling.
219
1st name | |
Middle name | |
Last name | Hideyuki Sawada |
Utano National Hospital
Clinical Research Center
8 Ondoyamacho, Narutaki, Ukyoku, Kyoto
81-75-461-5121
sawada@unh.hosp.go.jp
1st name | |
Middle name | |
Last name | Hideyuki Sawada |
Utano National Hospital
Clinical Research Center
8 Ondoyamacho, Narutaki, Ukyoku, Kyoto
81-75-461-5121
sawada@unh.hosp.go.jp
Utano National Hospital
Clinical Research Center, Utano National Hospital
NO
2015 | Year | 06 | Month | 19 | Day |
Published
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134118
Results
During the observation period 56 patients died. Baseline CRP was log-linearly associated with a risk of death in PD. Mean survival time was 3,149 (95% confidence interval; 3,009-3,289) days in patients with CRP =< 0.8mg/L (lower two thirds) and 2,620 (2,343-2,897) days in those with CRP > 0.8 mg/L (top third, p < 0.001, log-rank test). The adjusted hazard ratio (HR) per two-fold higher CRP concentration for all deaths was 1.29 (1.10-1.52), and after excluding PD-unrelated deaths, such as cancer or stroke, HR was 1.23 (1.01-1.49) (adjusted for age, sex, PD duration, modified Hohen-Yahr stages, MMSE scores, and serum albumin).
Conclusions
Baseline CRP concentrations were associated with the risk of death and predicted life prognosis of patients with PD. The associations were independent from PD duration, PD severity, cognitive function, ages, and nutritional conditions, suggesting the possibility that subclinical chronic inflammation is associated with a neurodegenerative process in PD.
Completed
2014 | Year | 05 | Month | 30 | Day |
2014 | Year | 06 | Month | 01 | Day |
A cohort of 313 patients with a mean age of 69.1 and mean PD duration of 7.9 years was retrospectively followed for a mean observation time of 1,753 days.CRP was measured when patients were not diagnosed with any infections, and levels were repetitively measured to investigate a tendency of "regression to mean." The primary outcome measure was a survival time from study enrollment to death.
2015 | Year | 06 | Month | 19 | Day |
2015 | Year | 07 | Month | 29 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020844
Research Plan | |
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Registered date | File name |
2015/06/19 | 研究計画書 CRP survival研究.docx |
Research case data specifications | |
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Registered date | File name |
Research case data | |
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Registered date | File name |
2015/06/19 | data set.xlsx |