Unique ID issued by UMIN | UMIN000017994 |
---|---|
Receipt number | R000020853 |
Scientific Title | Localization of specialized intestinal metaplasia and the molecular alterations in Barrett's esophagus in a Japanese population: an analysis of biopsy samples based on the "Seattle" biopsy protocol |
Date of disclosure of the study information | 2015/06/21 |
Last modified on | 2015/12/25 18:35:36 |
Localization of specialized intestinal metaplasia and the molecular alterations in Barrett's esophagus in a Japanese population: an analysis of biopsy samples based on the "Seattle" biopsy protocol
Phenotypic and molecular localization of BE
Localization of specialized intestinal metaplasia and the molecular alterations in Barrett's esophagus in a Japanese population: an analysis of biopsy samples based on the "Seattle" biopsy protocol
Phenotypic and molecular localization of BE
Japan |
Barrett's esophagus
Gastroenterology |
Others
YES
To clarify the differences of molecular alterations using four-quadrant biopsies from Barrett's esophagus (BE) based on the "Seattle" biopsy protocol
Bio-availability
To investigate the differences of molecular alterations related to carcinogenesis using four-quadrant biopsies based on the "Seattle" biopsy protocol
To investigate the differences of molecular alterations related to carcinogenesis between specialized intestinal metaplasia and columnar lined epithelium in Barrett's esophagus (BE)
Observational
Not applicable |
Not applicable |
Male and Female
Patients with Barrett's esophagus with more than 1 cm in diameter by endoscopy
(1) Patients with a history of esophagectomy or gastrectomy
(2) Patients having no application to the guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment from Japan Gastroenterological Endoscopy Society
(3) Patients who have determined by the physicians to have any reasons of unqualified
30
1st name | |
Middle name | |
Last name | Jiro Watari |
Hyogo College of Medicine
Division of Gastroenterology
1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
0798-45-6662
watarij@hyo-med.ac.jp
1st name | |
Middle name | |
Last name | Jiro Watari |
Hyogo College of Medicine
Division of Gastroenterology
1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
0798-45-6662
watarij@hyo-med.ac.jp
Division of Gastroenterology, Hyogo College of Medicine
None
Self funding
NO
2015 | Year | 06 | Month | 21 | Day |
Unpublished
1. MSI and hypermethylation at RUNX3, MGMT, hMLH1, p16 and APC genes were associated with BE carcinogenesis, but only APC gene hypermethylation was an independent predictive marker of EAC (OR=24.4, p=0.01) in the multivariate logistic regression analysis. In addition, the incidence of the these biomarkers did not show a significant difference between the 0-3 o'clock and 6-9 o'clock areas.
2. SIM was more frequently identified in the 0-3 o'clock quadrant than in the 6-9 o'clock quadrant (p=0.08).
3. The Ki-67 index was higher in SIM than in the columnar-lined epithelium (CLE) without goblet cells (p<0.0001), and in both SIM and CLE with Das-1 reactivity than in those without (p=0.04 and p=0.06, respectively).
4. The Ki-67 index was relatively higher in the 0-3 o'clock quadrant than in the 6-9 o'clock quadrant in cases with Das-1 reactivity.
Completed
2014 | Year | 08 | Month | 01 | Day |
2014 | Year | 08 | Month | 01 | Day |
2015 | Year | 04 | Month | 30 | Day |
2015 | Year | 08 | Month | 31 | Day |
1. RUNX3 methylation and Das-1 reactivity were more frequently found in SIM than in CLE (p=0.04 and p<0.0001, respectively).
2015 | Year | 06 | Month | 21 | Day |
2015 | Year | 12 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020853
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |