Unique ID issued by UMIN | UMIN000018272 |
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Receipt number | R000021149 |
Scientific Title | Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis |
Date of disclosure of the study information | 2015/07/11 |
Last modified on | 2015/12/28 16:13:38 |
Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis
Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis
Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis
Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis
Japan |
Mycobacterium tuberculosis
Medicine in general | Infectious disease |
Others
NO
Since 2010, studies on the diagnostic accuracy of TaqMan MTB (CTM) have been frequently reported with an unignorable discrepancy. Some previous studies suggested that these heterogeneous results may be caused by inconsistent smear status. The aim of the current systematic review and meta-analysis is to evaluate the sensitivity and specificity of CTM for culture-proven M tuberculosis with an emphasis on the impact of smear status.
Others
Since 2010, studies on the diagnostic accuracy of TaqMan MTB (CTM) have been frequently reported with an unignorable discrepancy. Some previous studies suggested that these heterogeneous results may be caused by inconsistent smear status. The aim of the current systematic review and meta-analysis is to evaluate the sensitivity and specificity of CTM for culture-proven M tuberculosis with an emphasis on the impact of smear status.
Others
Pragmatic
Not applicable
Pooled sensitiviey and pooled specificity by Cobas TaqMan MTB
Others,meta-analysis etc
0 | years-old | <= |
150 | years-old | > |
Male and Female
The inclusion criterion for this study was original studies that could provide sufficient data for calculating the sensitivity and/or the specificity of Cobas TaqMan MTB (CTM) for M tuberculosis or M tuberculosis complex. The reference test was Mycobacterium culture followed by TB confirmation. The composite reference standard combining the results of several reference tests was not allowed.
Not defined
1st name | |
Middle name | |
Last name | Nobuyuki Horita |
Yokohama City University Graduate School of Medicine
Department of Pulmonology
3-9 Fukuura, Kanazawa, Yokohama
045-352-7962.
horitano@yokohama-cu.ac.jp
1st name | |
Middle name | |
Last name | Nobuyuki Horita |
Yokohama City University Graduate School of Medicine
Department of Pulmonology
3-9 Fukuura, Kanazawa, Yokohama
045-352-7962.
horitano@yokohama-cu.ac.jp
Department of Pulmonology, Yokohama City University Graduate School of Medicine
None
Self funding
NO
2015 | Year | 07 | Month | 11 | Day |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673449/pdf/srep18113.pdf
Published
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673449/pdf/srep18113.pdf
Since 2010, studies on the diagnostic accuracy of COBAS TaqMan MTB (CTM) have been frequently reported with an unignorable discrepancy. The key inclusion criterion for this systematic review was original studies that could provide sufficient data for calculating the sensitivity and the specificity of CTM for M tuberculosis (TB) or M tuberculosis complex. The reference test was Mycobacterium culture. We used bivariate model for meta-analyses. Of the 201 candidate articles, we finally identified 17 eligible articles.Concerning the respiratory specimens, 1900 culture positive specimens and 20983 culture negative specimens from 15 studies were assessed. This provided the summary estimate sensitivity of 0.808 (95%CI 0.758-0.850) and the summary estimate specificity of 0.990 (95%CI 0.981-0.994). The area under curve was 0.956. The diagnostic odds ratio was 459 (95%CI 261-805, I(2) 26%). For the smear positive respiratory specimens, the sensitivity was 0.952 (95%CI 0.926-0.969) and the specificity was 0.916 (95%CI 0.797-0.968). For the smear negative respiratory specimens, the sensitivity and the specificity were 0.600 (95%CI 0.459-0.726) and 0.989 (95%CI 0.981-0.993), respectively. The diagnostic accuracy was poorer for the non-respiratory specimens, than for the respiratory specimens, but was acceptable. We believe that the information obtained from this study will aid physicians' decision making.
Main results already published
2015 | Year | 07 | Month | 11 | Day |
2015 | Year | 07 | Month | 11 | Day |
2015 | Year | 12 | Month | 09 | Day |
2015 | Year | 12 | Month | 09 | Day |
2015 | Year | 12 | Month | 09 | Day |
2015 | Year | 12 | Month | 09 | Day |
We conducted this meta-analysis following pre-specified protocol according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and standard guidelines for systematic review of diagnostic test accuracy. Quality of included studies was assessed by Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS2).18 Approval of Institutional Review Board was wavered for reviewing nature of the current study.
2015 | Year | 07 | Month | 11 | Day |
2015 | Year | 12 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000021149
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