Unique ID issued by UMIN | UMIN000018854 |
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Receipt number | R000021808 |
Scientific Title | efficacy of interferon-beta preceding sofosbuvir and ledipasvir combination therapy in genotype 1b HCV infected patients who failed to daclatasvir and asunaprevir therapy |
Date of disclosure of the study information | 2015/09/14 |
Last modified on | 2018/06/26 09:15:48 |
efficacy of interferon-beta preceding sofosbuvir and ledipasvir combination therapy in genotype 1b HCV infected patients who failed to daclatasvir and asunaprevir therapy
efficacy of interferon-beta preceding sofosbuvir and ledipasvir combination therapy
efficacy of interferon-beta preceding sofosbuvir and ledipasvir combination therapy in genotype 1b HCV infected patients who failed to daclatasvir and asunaprevir therapy
efficacy of interferon-beta preceding sofosbuvir and ledipasvir combination therapy
Japan |
genotype 1b HCV infected patients who failed to daclatasvir and asunaprevir combination therapy
Hepato-biliary-pancreatic medicine |
Others
NO
To evaluate the efficacy of interferon-beta preceding sofosbuvir and ledipasvir combination therapy in patients who failed to daclatasvir and asunaprevir combination therapy
Efficacy
level of serum HCV-RNA titer at 12 and 24 weeks after the treatment
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Interferon-beta 300 MIU, intravenous injection was carried out for 14 days every 12 hours twice a day, and oral SOF / LDP treatment (Harvoni) a day in the morning once for 84 days.
Not applicable |
Not applicable |
Male and Female
patients who failed to daclatsuvir and asunaprevir combination therapy
Less than the number of platelets 25 000 / mm3, ALT value of 500 U / mL or more
130
1st name | |
Middle name | |
Last name | Satochi Mochida |
Saitama Medical University
Department of Gastroenterology & Hepatology
38 Morohongo, Moroyama-Machi, Iruma-Gun, Saitama
049-276-1198
smochida@saitama-med.ac.jp
1st name | |
Middle name | |
Last name | Yoshihito Uchida |
Saitama Medical University
Department of Gastroenterology & Hepatology
38 Morohongo, Moroyama-Machi, Iruma-Gun, Saitama
049-276-1198
y_uchida@saitama-med.ac.jp
Department of Gastroenterology & Hepatology,
Saitama Medical University
Department of Gastroenterology & Hepatology,
Saitama Medical University
Self funding
NO
2015 | Year | 09 | Month | 14 | Day |
Published
Main results already published
2015 | Year | 08 | Month | 30 | Day |
2015 | Year | 09 | Month | 14 | Day |
2015 | Year | 08 | Month | 30 | Day |
2018 | Year | 06 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000021808
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