Unique ID issued by UMIN | UMIN000032048 |
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Receipt number | R000021969 |
Scientific Title | Diagnosis of gastric cancer by measuring the urinary porphyrins after oral administration of 5-aminolevulinic acid (ALA). |
Date of disclosure of the study information | 2018/04/01 |
Last modified on | 2019/04/02 16:38:57 |
Diagnosis of gastric cancer by measuring the urinary porphyrins after oral administration of 5-aminolevulinic acid (ALA).
Diagnosis of gastric cancer using urinary porphyrins.
Diagnosis of gastric cancer by measuring the urinary porphyrins after oral administration of 5-aminolevulinic acid (ALA).
Diagnosis of gastric cancer using urinary porphyrins.
Japan |
Gastric cancer
Hepato-biliary-pancreatic surgery |
Malignancy
NO
To determine whether the urinary levels of porphyrins after oral administration of 5-ALA are potential marker for diagnosis of gastric cancer.
Others
Study of the measurement method
Exploratory
The urinary and serum levels of porphyrins (5-ALA, uroporphyrin I and III, coproporphyrin I and III, protoporphyrin IX) after oral administration of 5-ALA in gastric cancer patients before and after gastrectomy and non-cancer patients.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Diagnosis
Medicine |
Measuring the urinary and serum levels of porphyrins after oral administration of 5-ALA (300mg) at the following points.
1. Gastric cancer patients 30 cases
1) before gastrectomy
2) after gastrectomy
3) every 6 months after gastrectomy
2. non-cancer patients 10 cases
20 | years-old | <= |
85 | years-old | > |
Male and Female
1) >=20 years old, <85 years old
2) Gastrectomy is scheduled for cSE gastric cancer.
3) patients who provide a written informed consent
1) Patients with severe anamnesis (Malignant hypertension. With severe congestive heart failure. Severe liver failure. Myocardial infarction within 3 months. End-stage cirrhosis. Poorly controlled diabetes. Severe pulmonary fibrosis. Interstitial pneumonia activity)
2) Patients who are able to orally intake foods.
3) Patients with porphyria or hypersensitivity to porphyrins allergy
4) Cancer patients within 5 years after treatment.
40
1st name | Hiroki |
Middle name | |
Last name | Akamatsu |
Osaka Police Hospital
Department of gastrointestinal surgery
543-0035
10-31 Kitayama-cho, Tennoji-ku, Osaka, Japan
06-6771-6051
h.akamatsu@me.com
1st name | Kentaro |
Middle name | |
Last name | Kishi |
Osaka Police Hospital
Department of gastrointestinal surgery
543-0035
10-31 Kitayama-cho, Tennoji-ku, Osaka, Japan
06-6771-6051
kishi-ke@oph.gr.jp
Osaka Police Hospital
None
Self funding
Drug supply and Sample measurement: SBI Phamaceuticals Co., Ltd
Osaka Police Hospital
10-31 Kitayama-cho, Tennoji-ku, Osaka, Japan
0667716051
shomu@oph.gr.jp
NO
大阪警察病院
2018 | Year | 04 | Month | 01 | Day |
Unpublished
Completed
2015 | Year | 04 | Month | 30 | Day |
2015 | Year | 05 | Month | 12 | Day |
2015 | Year | 09 | Month | 15 | Day |
2019 | Year | 03 | Month | 28 | Day |
2018 | Year | 04 | Month | 01 | Day |
2019 | Year | 04 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000021969
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