Unique ID issued by UMIN | UMIN000019321 |
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Receipt number | R000022333 |
Scientific Title | The CTNNB1 mutaion as a prognostic marker of sporadic desmoid tumors with meloxicam |
Date of disclosure of the study information | 2015/10/13 |
Last modified on | 2015/10/13 01:51:02 |
The CTNNB1 mutaion as a prognostic marker of sporadic desmoid tumors with meloxicam
The CTNNB1 mutaion of beta-catenin as a prognostic marker of sporadic desmoid tumors with meloxicam
The CTNNB1 mutaion as a prognostic marker of sporadic desmoid tumors with meloxicam
The CTNNB1 mutaion of beta-catenin as a prognostic marker of sporadic desmoid tumors with meloxicam
Japan |
sporadic desmoid tumor
Hematology and clinical oncology | Orthopedics |
Others
YES
To determine the significance of CTNNB1 (beta-catenin) mutations to predict treatment outcome in patients with desmoid tumors treated with meloxicam
Efficacy
Exploratory
Pragmatic
Not applicable
CTNNB1 exon3 mutation
efficacy of meloxicam treatment
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Medicine |
Meloxicam was administered orally at 10 mg/day
Not applicable |
Not applicable |
Male and Female
patients with extra abdominal, sporadic desmoid tumors were treated with meloxicam as a systemic medical therapy
familial adenomatous polyposis-associated desmoid tumor
33
1st name | |
Middle name | |
Last name | Yoshihiro Nishida |
Nagoya University Graduate School and School of Medicine
Department of Orthopaedic Surgery
65 Tsurumai, Showa-ku, Nagoya
052-744-1908
nishida@med.nagoya-u.ac.jp
1st name | |
Middle name | |
Last name | Shunsuke Hamada |
Nagoya University Graduate School and School of Medicine
Department of Orthopaedic Surgery
65 Tsurumai, Showa-ku, Nagoya
052-744-1908
shamada@med.nagoya-u.ac.jp
Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine
Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine
Self funding
Japan
NO
2015 | Year | 10 | Month | 13 | Day |
Published
All 4 cases with S45F mutation showed PD, and no cases in favorable group (0/20 cases) had S45F mutation(p=0.017), whereas cases with T41A or wild type did not show significant association with efficacy of meloxicam.
Completed
2003 | Year | 01 | Month | 01 | Day |
2003 | Year | 01 | Month | 01 | Day |
2013 | Year | 03 | Month | 31 | Day |
2013 | Year | 04 | Month | 30 | Day |
2013 | Year | 05 | Month | 31 | Day |
2013 | Year | 06 | Month | 30 | Day |
2015 | Year | 10 | Month | 13 | Day |
2015 | Year | 10 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022333
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