Unique ID issued by UMIN | UMIN000019604 |
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Receipt number | R000022350 |
Scientific Title | Study of perioperative antibiotics for tonsillectomy |
Date of disclosure of the study information | 2015/12/01 |
Last modified on | 2015/11/02 17:23:56 |
Study of perioperative antibiotics for tonsillectomy
Study of the effect by the preoperative azithromycine oral administration
Study of perioperative antibiotics for tonsillectomy
Study of the effect by the preoperative azithromycine oral administration
Japan |
chronic tonsillitis
obstructive sleep apnea syndrome
Oto-rhino-laryngology |
Others
NO
Study of the efficacy for the perioperative prevention of infection of the azithromycin oral administration
Efficacy
It is one week from beginning of dosage about fever, pain, bleeding
Observational
15 | years-old | < |
Not applicable |
Male and Female
The study population consisted of patients who were examined and underwent palatine tonsillectomy at Nagoya University Hospital.
Patients with a history of hypersensitivity to ingredients of the drugs to be prescribed, patients under 15 years of age, and those being treated with other antimicrobial agents were excluded from the study.
40
1st name | |
Middle name | |
Last name | Hironao Otake |
Nagoya University Graduate School of Medicine
Department of Otorhinolaryngology,Head and Neck surgery, Sleep Medicine
65 Tsurumai-cho, Showa-ku, Nagoya, Japan
0527442323
hiro07@med.nagoya-u.ac.jp
1st name | |
Middle name | |
Last name | Hironao Otake |
Nagoya University Graduate School of Medicine
Department of Otorhinolaryngology,Head and Neck surgery, Sleep Medicine
65 Tsurumai-cho, Showa-ku, Nagoya, Japan
0527442323
hiro07@med.nagoya-u.ac.jp
Nagoya University Graduate School of Medicine
none
Other
NO
2015 | Year | 12 | Month | 01 | Day |
Published
Completed
2013 | Year | 03 | Month | 12 | Day |
2013 | Year | 03 | Month | 12 | Day |
The study population consisted of patients who were examined and underwent palatine tonsillectomy at Nagoya University Hospital between August 2010 and February 2013. The disorders for which the surgical intervention was indicated were chronic tonsillitis, sleep apnea syndrome, tonsillar focal infection, and tonsillar hypertrophy. Patients with a history of hypersensitivity to ingredients of the drugs to be prescribed, patients under 15 years of age, and those being treated with other antimicrobial agents were excluded from the study.
Patients in the AZM treated group received a sustained release AZM preparation as a single 2 gram oral dose only once on Day 2 before the operation. Patients in the CEZ treated group were administered CEZ intravenously starting 30 minutes before initiation of the operation, at 4 hours postoperatively, and then twice daily for 3 days beginning on the day following the operation.
Assessments were made with respect to the incidence of SSI, that of postoperative bleeding, postoperative pain, duration of hospitalization, and adverse reactions possibly ascribable to drugs. As for SSI, the patients condition was judged according to the presence or absence of pyrexia, i.e. temperature above 38 degree, and hematologic or blood biochemical findings. The severity of postoperative pain was rated on the basis of the number of days on which the patient received non steroidal anti inflammatory drugs NSAIDs for pain management.
2015 | Year | 11 | Month | 02 | Day |
2015 | Year | 11 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022350
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