Unique ID issued by UMIN | UMIN000019625 |
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Receipt number | R000022685 |
Scientific Title | The mechanism of action of anti-inflammatory effects of propofol in macrophages |
Date of disclosure of the study information | 2015/11/09 |
Last modified on | 2019/05/07 10:44:50 |
The mechanism of action of anti-inflammatory effects of propofol in macrophages
The mechanism of action of anti-inflammatory effects of propofol in macrophages
The mechanism of action of anti-inflammatory effects of propofol in macrophages
The mechanism of action of anti-inflammatory effects of propofol in macrophages
Japan |
sepsis acute_respiratory_distress_syndrome surgical stress
Anesthesiology |
Others
NO
It is said to have anti-inflammatory effects in the intravenous anesthetics typified by propofol.
In this study, we aim to elucidate the mechanism of its anti-inflammatory action.
Efficacy
Production of inflammatory cytokines
Interventional
Parallel
Non-randomized
Open -no one is blinded
Dose comparison
2
Treatment
Medicine |
Propofol concentration was varied to observe the changes in macrophages
No propofol was varied to observe the changes in macrophages
20 | years-old | <= |
70 | years-old | >= |
Male and Female
In 20 years of age or older , history healthy people with no history we are interested in helping us to understand bled the significance of research
Patients with diabetes mellitus , hyperlipidemia , autoimmune diseases , have a steroid oral
3
1st name | Tsukasa |
Middle name | |
Last name | Kochiyama |
Juntendo university
Anesthesiology
113-0031
2-1-1Hongo, Bunkyo-ku, Tokyo
03-3813-3111
tsukasa.coach.1109@gmail.com
1st name | Tsukasa |
Middle name | |
Last name | Kochiyama |
Juntendo university
Anesthesiology
1130031
2-1-1Hongo, Bunkyo-ku, Tokyo
03-3813-3111
tsukasa.coach.1109@gmail.com
Juntendo university
juntendo university graduate school
Self funding
Juntendo University
2-1-1Hongo, Bunkyo-ku, Tokyo
03-3813-3111
ju-masui@juntendo-urayasu.jp
NO
2015 | Year | 11 | Month | 09 | Day |
https://doi.org/10.1155/2019/1919538
Published
https://doi.org/10.1155/2019/1919538
6
Propofol suppresses the progression of inflammation through the attenuation of IL-6 and IL-1-beta production in human M1 macrophages. Nrf2 is involved in the inhibitory activity of propofol via GABAA receptor during M1 polarization. Therefore, propofol administration can suppress postoperative inflammation following invasive surgical procedures.
2019 | Year | 05 | Month | 07 | Day |
Volunteer
Peripheral blood was obtained from healthy volunteers, all of whom provided written informed consent.
none
RT-PCR,ELISA,Western blot,siRNA
Main results already published
2015 | Year | 11 | Month | 01 | Day |
2015 | Year | 11 | Month | 07 | Day |
2015 | Year | 11 | Month | 09 | Day |
2018 | Year | 03 | Month | 31 | Day |
2018 | Year | 03 | Month | 31 | Day |
2015 | Year | 11 | Month | 04 | Day |
2019 | Year | 05 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022685
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