Unique ID issued by UMIN | UMIN000019701 |
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Receipt number | R000022756 |
Scientific Title | A multicenter, prospective observational study for the epidemiology of acute lung injury and acute respiratory distress syndrome |
Date of disclosure of the study information | 2015/11/16 |
Last modified on | 2020/11/12 10:34:19 |
A multicenter, prospective observational study for the epidemiology of acute lung injury and acute respiratory distress syndrome
Epidemiology of ALI/ARDS (FORECAST ARDS)
A multicenter, prospective observational study for the epidemiology of acute lung injury and acute respiratory distress syndrome
Epidemiology of ALI/ARDS (FORECAST ARDS)
Japan |
Acute lung injury, Acute respiratory distress syndrome
Emergency medicine |
Others
NO
The aim of this study was to elucidate the epidemiology, pathophysiology/pathogenesis, and diagnosis/treatment of acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) diagnosed by the AECC and Berlin definitions.
Others
28-day and hospital mortality
Exploratory
The epidemiology of ALI/ARDS (hospital mortality)
1. The pathophysiology and pathogenesis of ALI/ARDS
2. The diagnosis and therapeutic methods of ARDS
Observational
16 | years-old | <= |
Not applicable |
Male and Female
Patients who met the definition of ALI/ARDS according to the AECC (American European Consensus Conference)
None
500
1st name | Satoshi |
Middle name | |
Last name | GANDO |
Hokkaido University Graduate School of Medicine
Acute and Critical Care Medicine
060-8638
N15W7, Kita-ku, Sapporo
+81-11-706-7377
gando@med.hokudai.ac.jp
1st name | Shuta |
Middle name | |
Last name | Fukuda |
Japanese Association for Acute Medicine
Office
113-0033
3-3-12, Hongo, Bunkyo-ku, Tokyo
+81-3-5840-9870
http://www.jaam.jp/html/jaamforecast/index.html
jaam-10@umin.ac.jp
Japanese Association for Acute Medicine
Japanese Association for Acute Medicine, Japan Society for the Promotion of the Science
Other
Japan
Hokkaido University Hospital Clinical Research and Medical Innovation Center
N14W5, Kita-ku, Sapporo
+81-11-701-7636
crjimu@huhp.hokudai.ac.jp
NO
2015 | Year | 11 | Month | 16 | Day |
http://www.jaam.jp/html/jaamforecast/index.html
Published
https://www.ncbi.nlm.nih.gov/pubmed/31348148
166
CONCLUSIONS: Our study included a greater percentage of patients with ARDS with high severity and found that the overall mortality was 38%. The management of ARDS in Japan was characterized by high the utilization rate of glucocorticoids, which was positively associated with mortality.
2020 | Year | 05 | Month | 13 | Day |
2020 | Year | 05 | Month | 01 | Day |
PURPOSE: Acute respiratory distress syndrome (ARDS) remains a major cause of death. Epidemiology should be continually examined to refine therapeutic strategies for ARDS. We aimed to elucidate demographics, treatments, and outcomes of ARDS in Japan.
METHODS: This is a prospective cohort study for ARDS. We included adult patients admitted to intensive care units through emergency and critical care departments who satisfied the American-European Consensus Conference (AECC) acute lung injury (ALI) criteria. In addition, the fulfillment of the Berlin definition was assessed. Logistic regression analyses were used to examine the association of independent variables with outcomes.
Not applicable
RESULTS: Our study included 166 patients with AECC ALI from 34 hospitals in Japan; among them, 157 (94.6%) fulfilled the Berlin definition. The proportion of patients with PaO2/FIO2 lower than 100, patients under invasive positive pressure ventilation (IPPV), and in-hospital mortality was 39.2%, 92.2%, and 38.0% for patients with AECC ALI and 38.9%, 96.8%, and 37.6% for patients with Berlin ARDS, respectively. The area of lung infiltration was independently associated with outcomes of ARDS. Low-mid-tidal volume ventilation was performed in 75% of patients under IPPV. Glucocorticoid use was observed in 54% patients, and it was positively associated with mortality.
Completed
2015 | Year | 06 | Month | 05 | Day |
2016 | Year | 10 | Month | 28 | Day |
2016 | Year | 04 | Month | 01 | Day |
2017 | Year | 05 | Month | 31 | Day |
2017 | Year | 07 | Month | 31 | Day |
2017 | Year | 12 | Month | 31 | Day |
2018 | Year | 03 | Month | 31 | Day |
Study design: Prospective cohort study
Patients enrollment method; We recruit all patients who visit ER or are admitted to a ward of the participated hospitals between January 1 and December 31, 2016, fulfilling the AECC ALI criteria, butnot any of exclusion criteria.
Data collection: Relationships between patients' background factors (age, gender, comorbidities, etc), predisposing diseases, disease severity (P/F ratio), laboratory findings, organ dysfunction, etc and outcome (hospital mortality, 28-day mortality, hospital stay, ventilator-free days, etc)
2015 | Year | 11 | Month | 09 | Day |
2020 | Year | 11 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022756
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