Unique ID issued by UMIN | UMIN000019729 |
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Receipt number | R000022786 |
Scientific Title | Exploratory research of Expression of Acrolein and Vascular Adhesion Protein-1 (VAP-1) in Diabetic Retinopathy |
Date of disclosure of the study information | 2015/11/10 |
Last modified on | 2016/11/11 15:51:17 |
Exploratory research of Expression of Acrolein and Vascular Adhesion Protein-1 (VAP-1) in Diabetic Retinopathy
Acrolein and VAP-1 in Diabetic Retinopathy
Exploratory research of Expression of Acrolein and Vascular Adhesion Protein-1 (VAP-1) in Diabetic Retinopathy
Acrolein and VAP-1 in Diabetic Retinopathy
Japan |
Diabetic Retinopathy
Ophthalmology |
Others
NO
To measure the concentrations of acrolein and VAP-1 in the vitreous and serum samples obtained from patients with diabetic retinopathy
Others
To investigate the relationship between acrolein and VAP-1 in diabetic retinopathy
Concentrations of acrolein and soluble VAP-1 in the vitreous and serum samples obtained from patients with diabetic retinopathy
Observational
20 | years-old | <= |
90 | years-old | >= |
Male and Female
1. Patients with proliferative diabetic retinopathy (Study group)
2. Patients with idiopathic macular hole or epiretinal membrane (Control group)
3.Patients who had a detailed briefing of the study with explanatory documents prior to the enrollment and voluntarily signed a consent form
1. Patients with vitreous hemorrhage due to proliferative diabetic retinopathy
2. Patients with diabetes in control group
3.Patients who investigator considered inappropriate as a subject of this study
30
1st name | |
Middle name | |
Last name | Kousuke Noda |
Hokkaido University Graduate School of Medicine
Department of Ophthalmology
N-15, W-7, Kita-ku, Sapporo
011-706-5944
nodako@med.hokudai.ac.jp
1st name | |
Middle name | |
Last name | Kousuke Noda |
Hokkaido University Graduate School of Medicine
Department of Ophthalmology
N-15, W-7, Kita-ku, Sapporo
011-706-5944
nodako@med.hokudai.ac.jp
Department of Ophthalmology, Hokkaido University Graduate School of Medicine
Department of Ophthalmology, Hokkaido University Graduate School of Medicine
Other
NO
2015 | Year | 11 | Month | 10 | Day |
Unpublished
The present data show that 1) the levels of acrolein-conjugated protein and VAP-1/SSAO increase in the vitreous fluid of patients with diabetic retinopathy and 2) there is moderate positive correlation between acrolein-conjugated protein and VAP-1/SSAO.
Completed
2015 | Year | 10 | Month | 29 | Day |
2015 | Year | 11 | Month | 10 | Day |
A prospective observational study.
Vitreous samples will be collected from patients with proliferative diabetic retinopathy and non-diabetic ocular diseases, i.e., epiretinal membrane (ERM) and idiopathic macular hole (MH), who underwent pars plana vitrectomy in Hokkaido University Hospital from 2015/11 to 2016/3.
The amounts of acrolein-conjugated protein, VAP-1/SSAO, oxidative stress marker, and enzymatic activity of VAP-1/SSAO will be evaluated.
2015 | Year | 11 | Month | 10 | Day |
2016 | Year | 11 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022786
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