Unique ID issued by UMIN | UMIN000020108 |
---|---|
Receipt number | R000023228 |
Scientific Title | Establishment of screening system for identifying ng high-risk individuals for developing diabetic macroangiopathy using carotid ultrasound |
Date of disclosure of the study information | 2015/12/07 |
Last modified on | 2018/12/09 16:30:38 |
Establishment of screening system for identifying ng high-risk individuals for developing diabetic macroangiopathy using carotid ultrasound
Establishment of diabetic macroangiopathy screening system using carotid ultrasound
Establishment of screening system for identifying ng high-risk individuals for developing diabetic macroangiopathy using carotid ultrasound
Establishment of diabetic macroangiopathy screening system using carotid ultrasound
Japan |
diabetes
Endocrinology and Metabolism |
Others
NO
The aim of this study is as follows:
(1) To evaluate whether carotid ultrasound can add prognostic information beyond conventional cardiovascular risk markers in patients with diabetes.
(2) To determine the cut-off value of carotid IMT to identify high-risk individuals for developing cardiovascular events.
(3) To determine the optimal inspection interval.
(4) To evaluate whether the progression of carotid IMT can be used as a surrogate endpoint of cardiovascular events.
Others
Usefulness of the clinical test
Whether carotid ultrasound can add prognostic information beyond conventional cardiovascular risk markers in patients with diabetes.
Others,meta-analysis etc
Not applicable |
Not applicable |
Male and Female
N/A
(Recruitment of new subjects for this study is not considered. The present study was an integration analysis and based on the fixed data obtained from 3 prospective observational studies and 2 clinical trials in Japanese diabetic patients, where carotid IMT was measured at baseline and the occurrence of a cardiovascular event during the follow-up period was recorded.)
N/A
3707
1st name | |
Middle name | |
Last name | Naoto Katakami |
Osaka University Graduate School of Medicine
Department of Metabolic Medicine
2-2, Yamadaoka, Suita, Osaka
06-6879-3743
katakami@endmet.med.osaka-u.ac.jp
1st name | |
Middle name | |
Last name | Naoto Katakami |
Osaka University Graduate School of Medicine
Department of Metabolic Medicine
2-2, Yamadaoka, Suita, Osaka
06-6879-3743
katakami@endmet.med.osaka-u.ac.jp
Osaka University Graduate School of Medicine, Department of Metabolic Medicine
Non
Self funding
NO
2015 | Year | 12 | Month | 07 | Day |
Published
Based on a combined analysis of data obtained in five longitudinal studies including a total of 3263 patients with diabetes, we found addition of carotid ultrasonography measures to conventional risk factors significantly improved stratification of patients by cardiovascular risk. Notably, increment of carotid IMT and GSM during the observation period were also prognostic factors for CVD even after adjusting for the baseline value of the respective measure.
Completed
2015 | Year | 12 | Month | 07 | Day |
2016 | Year | 02 | Month | 01 | Day |
2017 | Year | 12 | Month | 31 | Day |
The present study was an integration analysis and based on the fixed data obtained from 3 prospective observational studies and 2 clinical trials in Japanese diabetic patients, where carotid IMT was measured at baseline and the occurrence of a cardiovascular event during the follow-up period was recorded.
2015 | Year | 12 | Month | 07 | Day |
2018 | Year | 12 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023228
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |