Unique ID issued by UMIN | UMIN000020143 |
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Receipt number | R000023266 |
Scientific Title | Randomized controlled study for assessing effectiveness of hypercapnia on quality of emergence from general anesthesia in adults |
Date of disclosure of the study information | 2015/12/10 |
Last modified on | 2018/05/31 05:32:28 |
Randomized controlled study for assessing effectiveness of hypercapnia on quality of emergence from general anesthesia in adults
hypercapnia and quality of emergence from general anesthesia
Randomized controlled study for assessing effectiveness of hypercapnia on quality of emergence from general anesthesia in adults
hypercapnia and quality of emergence from general anesthesia
Japan |
Adult patients undergoing abdominal sugeries under general anesthesia combined with epidural anesthesia
Gastrointestinal surgery | Hepato-biliary-pancreatic surgery | Anesthesiology |
Adult |
Malignancy
NO
To test a hypothesis that hypercapnia shortens emergence from general anesthesia and stabilizes cardio-respiratory functions, and to explore interactions between consciousness level and cardio-respiratory functions.
Efficacy
emergence time from cessation of general anesthetics
Critical cardio-respiratory events
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
Dose comparison
YES
2
Treatment
Other |
normocapnia: ET-CO2 30-35 mmHg is maintained until emergence from anesthesia.
hypercapnia: ET-CO2 is gradually reduced from 60-65 mmHg until emergence from anesthesia
20 | years-old | <= |
70 | years-old | >= |
Male and Female
1. Patients scheduled for invasive arterial blood pressure monitoring
2. Patients scheduled for general anesthesia combined with epidural anesthesia
3. Patients undergoing abdominal surgeries
1. Patients with ASA (American Society of Anesthesiologists) physical status greater than 3
2. Patients with abnormal upper airway
3. Patients with asthma
4. Patients with post-head and neck surgeries
5. Patients with COPD (%FEV1.0<70%)
6. Patients with tracheostomy
7. Patients with intra-cranial pathologies
8. Patients with hypoxemia at emergence from anesthesia
9. Patients without indication for extubation in the operating room
50
1st name | |
Middle name | |
Last name | Shiroh Isono |
Graduate School of Medicine, Chiba University
Anesthesiology
1-8-1 Inohana-cho, Chuo-ku, Chiba
043-22-7171
shirohisono@yahoo.co.jp
1st name | |
Middle name | |
Last name | Shiroh Isono |
Graduate School of Medicine, Chiba University
Department of Anesthesiology
1-8-1 Inohana-cho, Chuo-ku, Chiba
043-222-7171
shirohisono@yahoo.co.jp
Chiba University Hospital
Japanese grant-in-aid (4390363) from the Ministry of Education, Culture, Sports, Science and Technology
Japan
NO
千葉大学医学部附属病院
2015 | Year | 12 | Month | 10 | Day |
Unpublished
Completed
2015 | Year | 11 | Month | 17 | Day |
2015 | Year | 12 | Month | 15 | Day |
2015 | Year | 12 | Month | 10 | Day |
2018 | Year | 05 | Month | 31 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023266
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