Unique ID issued by UMIN | UMIN000020210 |
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Receipt number | R000023327 |
Scientific Title | Effects of isohumulones on endothelial function in healthy volanteers |
Date of disclosure of the study information | 2015/12/16 |
Last modified on | 2017/02/21 22:00:16 |
Effects of isohumulones on endothelial function in healthy volanteers
Effects of isohumulones
Effects of isohumulones on endothelial function in healthy volanteers
Effects of isohumulones
Japan |
healthy, cardiovasucular disease
Adult |
Others
NO
To evaluate for the improvement ofimprovement of endothelial functions after oral ingestion of isohumulones, bitter components of beer
Efficacy
Exploratory
Pragmatic
Phase I
Flow mediated dilatation(FMD) in same day
glucose, insulin, triglyceride,
Interventional
Cross-over
Randomized
Individual
Double blind -all involved are blinded
Placebo
Institution is not considered as adjustment factor.
2
Treatment
Food |
intake placebo
washout 2days
Intake Hop cupsels which contains isohumulones about 10mg/10kg
Intake Hop cupsels which contains isohumulones about 10mg/10kg
washout(2days)
intake placebo
20 | years-old | <= |
60 | years-old | >= |
Male
healthy volanteers
none
15
1st name | |
Middle name | |
Last name | Junko Tomita |
Kasaoka City Hospital
Cardiology
Kasaoka 5628-1 Kasaoka City
0865-63-2191
tomita-j@kasaokacityhsp.jp
1st name | |
Middle name | |
Last name | Junko Tomita |
Kasaoka city Hospital
Cardiology
Kasaoka 5628-1, Kasaoka city
0865-63-2191
tomita-j@kasaokacityhsp.jp
Kasaoka City Hospital
Ksaoka City Hospital
Self funding
NO
笠岡市立市民病院(岡山県)
2015 | Year | 12 | Month | 16 | Day |
Published
Twelve cigarette smokers and eleven non-smokers ingested IHE and placebo in a randomized crossover design. Flow-mediated vasodilatation (FMD) was measured using ultrasonography. The FMDs increased significantly after IHE ingestion in both the smokers and the non- smokers. Oral ingestion of IHE appears to exert acute beneficial effects on the endothelial functions in both the smokers and non-smokers.
Completed
2015 | Year | 07 | Month | 10 | Day |
2015 | Year | 12 | Month | 16 | Day |
2016 | Year | 03 | Month | 16 | Day |
2016 | Year | 06 | Month | 30 | Day |
2015 | Year | 12 | Month | 15 | Day |
2017 | Year | 02 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023327
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