Unique ID issued by UMIN | UMIN000020408 |
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Receipt number | R000023569 |
Scientific Title | The short-term and long-term effect on meibomian gland dysfunction with dry eye by Diquafosol Sodium eye drop |
Date of disclosure of the study information | 2016/01/01 |
Last modified on | 2018/03/16 09:19:22 |
The short-term and long-term effect on meibomian gland dysfunction with dry eye by Diquafosol Sodium eye drop
The effect on MGD with dry eye by Diquafosol Sodium eye drop
The short-term and long-term effect on meibomian gland dysfunction with dry eye by Diquafosol Sodium eye drop
The effect on MGD with dry eye by Diquafosol Sodium eye drop
Japan |
Normal eyes
Ophthalmology |
Others
NO
Diquafosol, which is commercially available in Japan as a novel dry eye therapy, is a P2Y2 purinergic receptor agonist that activates P2Y2 receptors on the ocular surface, leading to rehydration through activation of the fluid pump of the accessory lacrimal glands on the conjunctival tissue and conjunctival goblet cell secretion of ocular mucins.
P2Y2 receptors exist in the meibomian glands as well. The present study was designed to evaluate the shor-term and long-term effect of diquafosol 3% ophthalmic solution (Diquas, Santen, Osaka, Japan) when applied to normal.
Efficacy
Confirmatory
Not applicable
Lipid layer thickness
Symtoms, tear-film break up time (TBUT), tear meniscus, meibography, Schirmer tess
Interventional
Parallel
Randomized
Individual
Single blind -investigator(s) and assessor(s) are blinded
Placebo
YES
YES
Institution is not considered as adjustment factor.
NO
Numbered container method
2
Treatment
Medicine |
Diquafosol eyedrop 6 times a day for 4 weeks
Artificial tear eyedrop 6 times a day for 4 weeks
20 | years-old | <= |
65 | years-old | >= |
Male and Female
Normal eyes without dry eye symptoms
Normal subjects with any other ocular disease (except cataract, refractive error) .
The history of contact lens wear. Subjects without written informed consent.
50
1st name | |
Middle name | |
Last name | Reiko Arita |
Itoh Clinic
Department of Ophthalmology
626-11 Minami-Nakano, Minuma, Saitama, Saitama 337-0042, Japan
048-686-5588
arita.reiko@gmail.com
1st name | |
Middle name | |
Last name | Arita Reiko |
Itoh Clinic
Department of Ophthalmology
626-11 Minami-Nakano, Minuma, Saitama, Saitama 337-0042, Japan
048-686-5588
arita.reiko@gmail.com
Itoh Clinic
Itoh Clinic
Other
NO
伊藤医院(埼玉県)
2016 | Year | 01 | Month | 01 | Day |
Published
Completed
2015 | Year | 12 | Month | 01 | Day |
2016 | Year | 01 | Month | 01 | Day |
2017 | Year | 12 | Month | 31 | Day |
2018 | Year | 01 | Month | 31 | Day |
2018 | Year | 01 | Month | 31 | Day |
2018 | Year | 03 | Month | 31 | Day |
2015 | Year | 12 | Month | 31 | Day |
2018 | Year | 03 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023569
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