Unique ID issued by UMIN | UMIN000020430 |
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Receipt number | R000023579 |
Scientific Title | Measurement of Cough Response to Bronchoconstriction Induced by Methacholine: An Examination Using the Astograph Method |
Date of disclosure of the study information | 2016/01/04 |
Last modified on | 2016/01/04 20:51:46 |
Measurement of Cough Response to Bronchoconstriction Induced by
Methacholine: An Examination Using the Astograph Method
Cough Response to Bronchoconstriction induced by Methacholine using the Astograph Method
Measurement of Cough Response to Bronchoconstriction Induced by
Methacholine: An Examination Using the Astograph Method
Cough Response to Bronchoconstriction induced by Methacholine using the Astograph Method
Japan |
cough variant asthma
Pneumology | Clinical immunology | Adult |
Others
NO
The relationship in the cough response to bronchoconstriction induced by the methacholine provocation using the original method and the astograph method
Bio-equivalence
The total number of cough induced by two methods
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Diagnosis
Medicine | Device,equipment |
day1 The measurement of cough response to bronchoconstriction induced by Methacholine using original method
day2 The measurement of cough response to bronchoconstriction induced by Methacholine using Astograph method
Twofold increasing concentrations of methacholine chloride diluted in physiologic saline in 13 dose steps (0.04 to 160 mg/mL) were prepared.
Original method
Methacholine was inhaled for 2 minutes by tidal breathing with the patient wearing a nose clip, which was followed immediately by measurements of partial and full flow-volume curves. Increasing concentrations of Methacholine were inhaled until a decrease of 35% or more in PC35-PEF40 from the baseline value occurred.
Coughs were counted for 2 minutes during the inhalation and for 30 minutes after the inhalation of Mch at concentrations of PC35-PEF40.
Astograph method
Methacholine inhalation challenge was performed by an astograph (Jupiter 21; CHEST; Tokyo, Japan), according to the method of Takishima et al. Briefly, respiratory resistance was measured by the forced oscillation method (3 Hz) during continuous inhalation of Methacholine in stepwise incremental concentrations, until Rrs reached twice the baseline value. Spirometry was measured before Methacholine inhalation challenge and immediately after the Rrs had increased twofold. At that time, if FEV1 did not decreased less than 90% of baseline value, inhalation of Methacholine was restarted at the same concentration. Coughs were counted manually by an observer, and cough counts for the interval beginning < 1min before, and for 30 min following inhalation of Methacholine at which Rrs and FEV1were archived.
20 | years-old | <= |
29 | years-old | >= |
Male and Female
Subjects with non-smoker, aged 20 to 29 years were eligible for the study.
Subjects were excluded if they had a history of bronchial asthma, any clinically significant respiratory disorders, tachyarrhythmia, heart failure or disorder that might put them at risk or influence the study results or their ability to participate.
40
1st name | |
Middle name | |
Last name | Johsuke hara |
Kanazawa University Graduate School of Medicine
Respiratory Medicine, Cellular Transplantation Biology
13-1, Takara-machi, Kanazawa, Ishikawa, Japan
076-265-2000
hara0728@gmail.com
1st name | |
Middle name | |
Last name | Johsuke hara |
Kanazawa University Graduate School of Medicine
Respiratory Medicine, Cellular Transplantation Biology
13-1, Takara-machi, Kanazawa, Ishikawa, Japan
076-265-2000
hara0728@gmail.com
Kanazawa University Graduate School of Medicine
Kanazawa University Graduate School of Medicine
Other
NO
金沢大学附属病院
2016 | Year | 01 | Month | 04 | Day |
Unpublished
Open public recruiting
2014 | Year | 09 | Month | 25 | Day |
2014 | Year | 09 | Month | 25 | Day |
2016 | Year | 01 | Month | 04 | Day |
2016 | Year | 01 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023579
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