Unique ID issued by UMIN | UMIN000020542 |
---|---|
Receipt number | R000023717 |
Scientific Title | Fibrosis in Childhood Interstitial Lung Diseases: Correlation with Clinical Characteristics |
Date of disclosure of the study information | 2016/01/15 |
Last modified on | 2017/02/16 14:44:43 |
Fibrosis in Childhood Interstitial Lung Diseases: Correlation with Clinical
Characteristics
Fibrosis in Childhood Interstitial Lung Diseases
Fibrosis in Childhood Interstitial Lung Diseases: Correlation with Clinical
Characteristics
Fibrosis in Childhood Interstitial Lung Diseases
Africa |
Childhood Interstitial Lung Diseases
Pneumology | Child |
Others
NO
To evaluate fibrosis and lung elastin destruction in pediatric patients with interstitial lung disease (chILD) during acute exacerbation and to correlate findings with demographic, clinical characteristics and outcome.
Safety
Markers of fibrosis (TGF-beta1, sFas, CCN2) and elastin destruction (UDes/UCr) were increased in chILD. So blockage of their pathways signals may offer novel therapeutic targets.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Other |
markers of fibrosis
2 | years-old | <= |
5 | years-old | >= |
Male and Female
chILD diagnostic criteria were at least three of following criteria: (1)
respiratory symptoms (e.g., cough, rapid and/or difficult breathing, or exercise
intolerance); (2) respiratory signs (e.g., resting tachypnea, adventitious sounds,
retractions, digital clubbing, failure to thrive, or respiratory failure); (3) hypoxemia;
(4) diffuse abnormalities on chest X-ray (CXR) or high resultion computed
tomography (HRCT).
Patients were excluded from this study if they
hadbronchopulmonary dysplasia, congenital heart disease, primary or acquired
immunodeficiency, primary autoimmune disorder, cystic fibrosis or pulmonary
tuberculosis.
50
1st name | |
Middle name | |
Last name | Khaled Saad |
Assiut university
faculty of medicine
Faculty of Medicine, Assiut University, Assiut, Egypt
+20882413683
med@aun.edu.eg
1st name | |
Middle name | |
Last name | Khaled Saad |
Faculty of medicine, University of Assiut, Assiut 71516, Egypt.
Faculty of medicine
Faculty of medicine, University of Assiut, Assiut 71516, Egypt.
+20882368373
med@aun.edu.eg
Grant office, Faculty of Medicine, Assiut University, Assiut, Egypt
Grant office, Faculty of Medicine, Assiut University, Assiut, Egypt, grant number (1317), grant office number +20882413683
Other
NO
2016 | Year | 01 | Month | 15 | Day |
Published
Markers of fibrosis (TGF-beta1, sFas, CCN2) and elastin destruction (UDes/UCr) were increased in chILD. blockage of their pathways signals may offer novel therapeutic targets.
Main results already published
2012 | Year | 01 | Month | 01 | Day |
2012 | Year | 06 | Month | 01 | Day |
2015 | Year | 06 | Month | 01 | Day |
2015 | Year | 07 | Month | 01 | Day |
2015 | Year | 08 | Month | 01 | Day |
2015 | Year | 10 | Month | 01 | Day |
blockage of their pathways signals may offer novel therapeutic targets.
2016 | Year | 01 | Month | 13 | Day |
2017 | Year | 02 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023717
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