Unique ID issued by UMIN | UMIN000020680 |
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Receipt number | R000023863 |
Scientific Title | The effects of sevoflurane on the QT interval in patients with diabetes |
Date of disclosure of the study information | 2016/01/21 |
Last modified on | 2018/02/01 12:00:44 |
The effects of sevoflurane on the QT interval in patients with diabetes
The effects of sevoflurane on the QT interval in patients with diabetes
The effects of sevoflurane on the QT interval in patients with diabetes
The effects of sevoflurane on the QT interval in patients with diabetes
Japan |
diabetes
Cardiology | Anesthesiology |
Others
NO
The purpose of this study is to investigate the effects on the ECG QT interval by sevoflurane in diabetes
Pharmacodynamics
ECG QTc interval
Sevoflurane administration before and
After administration, 5 minutes, 10 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes
ECG Tp-e interval
Sevoflurane administration before and
After administration, 5 minutes, 10 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes
Observational
20 | years-old | <= |
Not applicable |
Male and Female
general anesthetic patient
Heart surgery
Pregnant woman
Atrial fibrillation
Bundle branch block
74
1st name | |
Middle name | |
Last name | Seishi Kimura |
Kindai University Faculty of Medicine
Department of Anesthesiology
377-2 Ohno-higashi, Osaka-sayama 589-8511, Japan
072-366-0221
s-kimura@med.kindai.ac.jp
1st name | |
Middle name | |
Last name | Seishi Kimura |
Kindai University Faculty of Medicine
Department of Anesthesiology
377-2 Ohno-higashi, Osaka-sayama 589-8511, Japan
072-366-0221
s-kimura@med.kindai.ac.jp
Department of Anesthesiology, Kindai University Faculty of Medicine
Department of Anesthesiology, Kindai University Faculty of Medicine
Self funding
NO
近畿大学医学部附属病院
2016 | Year | 01 | Month | 21 | Day |
Published
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188555
In the hyperglycemic group, the QTc interval is extended, but the Tp - ec interval is not prolonged.
Completed
2013 | Year | 11 | Month | 15 | Day |
2014 | Year | 09 | Month | 01 | Day |
2017 | Year | 12 | Month | 01 | Day |
2017 | Year | 12 | Month | 01 | Day |
2017 | Year | 12 | Month | 01 | Day |
2017 | Year | 12 | Month | 01 | Day |
We enrolled normoglycemic patients (HbA1c: <6.5%) (NG group) and chronically hyperglycemic patients (HbA1c: >=6.5%) (HG group). The QT interval and Tp-e interval (from the peak to the end of the T wave were measured before and at 5, 10, 30, 60, 90, and 120 min after sevoflurane administration, and corrected for the RR interval using Bazett's formula (QTc and Tp-ec)
This research is a prospective study.
Those subjects who underwent surgery at the institution starting January 2016 were eligible for selection criteria.
2016 | Year | 01 | Month | 21 | Day |
2018 | Year | 02 | Month | 01 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023863
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