Unique ID issued by UMIN | UMIN000021090 |
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Receipt number | R000024266 |
Scientific Title | A Basic Study for Pancreatic islet-like cells derived from iPS cells: Establishment of Stable Cellular Delivery System |
Date of disclosure of the study information | 2016/03/01 |
Last modified on | 2018/02/19 14:49:30 |
A Basic Study for Pancreatic islet-like cells derived from iPS cells: Establishment of Stable Cellular Delivery System
A Basic Study for Pancreatic islet-like cells derived from iPS cells
A Basic Study for Pancreatic islet-like cells derived from iPS cells: Establishment of Stable Cellular Delivery System
A Basic Study for Pancreatic islet-like cells derived from iPS cells
Japan |
Pancreatic diseases which are needed pancreatectomy
Surgery in general | Hepato-biliary-pancreatic surgery |
Malignancy
NO
We plan these preclinical studies described below for utilizing pancreatic islet-like cells derived from iPS cells in clinical setting.
Delivering islet-like cells derived from iPS cells from DefiniGEN (England) to Tohoku University and evaluating the endocrinal function of the cells before and after delivery, and certifying the safety of the cells using transplant animal models.
Making islet-like cells via iPS cells which are differentiated from blood samples taken from persons in health and patients who receive pancreatectomy. The endocrinal function and safety are evaluated.
Safety,Efficacy
Exploratory
Pragmatic
Not applicable
1) Comparing insulin releasing function by glucose stimulation between pre- and post-derivery
2) Comparing viability defined as ratio between viable cells and total cells between pre- and post-derivery
3) Evaluating safety in tumogenesis using transplant animal model
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Maneuver |
taking blood sample
18 | years-old | <= |
Not applicable |
Male and Female
Persons in health and patients who need pancreatectomy. Candidates as persons in health are defined as persons who receive explanation about this study, understand the theme, and sign the consent form. The consents are provided under their will. There are no matters about the disease for pancreatectomy in the case of patients who need pancreatectomy.
Patients in emergency
Patients who cannot have a consent by themselves (i.e.persons under 18 years old)
Patients in difficult hemostasis condition
10
1st name | |
Middle name | |
Last name | Naoaki Sakata |
Tohoku University School of Medicine
Surgery
1-1 Seiryomachi, Aobaku, Sendai
022-717-7205
n-sakata@surg1.med.tohoku.ac.jp
1st name | |
Middle name | |
Last name | Naoaki Sakata |
Tohoku University School of Medicine
Surgery
1-1 Seiryomachi, Aobaku, Sendai
022-717-7205
n-sakata@surg1.med.tohoku.ac.jp
Department of Surgery, Tohoku University School of Medicine
National Cancer Center
Other
NO
2016 | Year | 03 | Month | 01 | Day |
Unpublished
Preinitiation
2016 | Year | 01 | Month | 19 | Day |
2016 | Year | 01 | Month | 19 | Day |
2018 | Year | 03 | Month | 31 | Day |
2016 | Year | 02 | Month | 18 | Day |
2018 | Year | 02 | Month | 19 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024266
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